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The role of inflammation in the pathophysiology of DMO

1 February 2016 | | EYE - Vitreo-Retinal
Diabetic macular oedema (DMO) is a major cause of visual loss in diabetes, with a complex multifactorial pathogenesis. In the UK alone it is estimated that there are nearly 2.5 million diabetic patients aged over 12 years. Approximately 65,000 of...

Melanocytoma of the optic disc

1 June 2015 | | EYE - Cataract, EYE - Cornea, EYE - General, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Oncology, EYE - Orbit, EYE - Paediatrics, EYE - Pathology, EYE - Refractive, EYE - Strabismus, EYE - Vitreo-Retinal
Melanocytoma is a heavily pigmented lesion, composed of melanocytes and is a variant of melanocytic naevus. It classically occurs at the optic disc and is usually benign, static and asymptomatic. However, it can occasionally grow and invade the retina or...

Identifying drugs associated with intraoperative floppy iris syndrome

1 April 2016 | | EYE - Cataract, EYE - Refractive
Before David Chang MD from the University of California found out about intraoperative floppy iris syndrome (IFIS), ophthalmologists were mystified each time they came across cataract surgeries that were characterised by sudden intraoperative iris prolapse and pupil constriction. The biggest...

Don’t ignore the black lesion! It might be mucormycosis

1 June 2017 | | EYE - Cornea
Keeping mucormycosis infection in the foreground of your differential diagnosis, especially in those more vulnerable patients, will help save their lives if recognised and managed appropriately. Mucormycosis is a fulminant infection caused by the fungi of the family Mucoraceae. It...

Ocular bubbly: a vitreoretinal update on the art of gases

5 April 2022 | | EYE - Vitreo-Retinal, EYE - General
The authors remind us of the revolutionary impact gases have had on retinal surgery. In 1938, Rosengren attempted to improve his retina repair surgical outcomes [1]. He discovered that suturing the retina or pressing externally on the sclera were not...

Childhood glaucoma

2 October 2025 | | EYE - Paediatrics, EYE - Glaucoma
When a child is given a diagnosis of glaucoma, the impact upon that child and their family is enormous; equivalent to the diagnosis of a cancer [14]. This previously published article (2019) outlines the knowledge, techniques and approaches that offer...

Radiation retinopathy

5 June 2020 | | EYE - Vitreo-Retinal, EYE - General
The authors review the current treatment options for this condition. Radiation retinopathy (RR) occurs as a complication after exposure to any type of radiation (external beam, plaque brachytherapy and stereotactic radiosurgery) in the orbital or adnexal region. These include nasopharyngeal...

Management of proliferative diabetic retinopathy

1 August 2014 | | EYE - Vitreo-Retinal
Diabetic retinopathy is a major cause of blindness in the working-age population. Due to the worsening global epidemic of diabetes, the incidence of morbidity caused by the disease is set to increase [1]. The prevalence of diabetes in the UK...

Addressing medical risk factors for diabetes and understanding the new systemic treatments

1 February 2014 |
As global diabetes figures continue to rise, the importance of reducing the burden of macrovascular and microvascular complications of diabetes has never been so great. By 2025 it is estimated that five million people in the UK will have diabetes...

100 years of insulin

3 October 2022
*Joint first authors The centenary of the discovery of insulin is a time to celebrate one of the most significant scientific discoveries of the 20th century. Background Before 1923, Type 1 diabetes mellitus [T1DM] resulted in death from severe ketoacidosis...

A Multidisciplinary Approach to Neovascular Glaucoma in a Patient with Waldenström’s macroglobulinemia

1 December 2013 |
An 84-year-old Caucasian male attended eye casualty with a four month history of reduced vision, a dull ache and photophobia in both eyes. He had also reported dizziness, weakness and intermittent epistaxis in the nine months prior to presentation. There...

SOS (Simplified Ophthalmic Statistics) Part 4: How to present your statistical analysis

1 October 2019 | | EYE - General
This is the last in this series of short guides which we hope provide some guidance in relation to statistical issues researchers may encounter when conducting research, audit or indeed quality improvement projects. Here we focus on an issue that...