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Case Reports

A slit-lamp image showing crystalline deposits at the peripheries of the cornea.

Crystalline keratopathy in monoclonal gammopathy of undetermined significance

2 April 2025 | Kar Yen Phoong | EYE - Cornea

Monoclonal gammopathies encompass a group of plasma cell disorders characterised by the excessive production of abnormal monoclonal immunoglobulins in the bloodstream [1]. This category includes multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), amyloidosis and other lymphoproliferative disorders. Monoclonal gammopathy...

Behind the eyes: Unravelling the mystery of a painless progressive proptosis

4 February 2025 | Netra Kalla, Tristan McMullan | EYE - Oculoplastic, EYE - Orbit, EYE - Pathology

Orbital fungal infections have the potential to give rise to serious complications. While these infections typically originate in the sinuses, patients may initially exhibit ocular symptoms. As a result of the diverse and often vague clinical manifestations (especially during the...

Widefield fundus image.

Pigmented paravenous retinochoroidal atrophy

4 December 2024 | William Spackman, Tun Giap Tan, Stephen Turner | EYE - Imaging, EYE - Vitreo-Retinal

Presentation A 46-year-old Caucasian female was referred to the eye clinic by her local optician following a routine sight test. She was noted to have pigmentary retinal changes in both eyes but was asymptomatic with no visual complaints. At presentation...

Image showing early signs of stromal rejection with an area of superior conjunctival injection.

Presumed DALK stromal graft rejection following Covid-19 infection

4 December 2024 | Mary-Therese Monaghan, Shokufeh Tavassoli | EYE - Cornea

Case report A 45-year-old healthy male patient with a past ocular history of keratoconus and right deep-anterior lamellar keratoplasty (DALK) graft performed 10 months prior, presented to our eye casualty clinic with a two-day history of right photophobia and epiphora....

Neurofibromatosis with multiple bilateral choroidal nevi and literature review

14 November 2024 | Mehru-Nisah Hanif, Syed Raza Ali Zaidi, Nausheen Hayat | EYE - Imaging, EYE - Oncology, EYE - Vitreo-Retinal

The aim is to present a case of neurofibromatosis type-1 (NF-1), also known as von Recklinghausen disease, who presented with bilateral multiple choroidal nodular nevi following chemotherapy and mastectomy for breast cancer. Neurofibromatosis type-1 presents as a wide range of...

Image showing patient presented several months later with upper and lower lip painless oedema.

Melkersson-Rosenthal syndrome

3 October 2024 | Aline Derlagne, Antigoni Koukkoulli, Katia Papastavrou, Loukiana Tsierkezou, Theodoros Potamitis | EYE - Neuro-ophthalmology

Melkersson-Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous disorder which is defined by a triad of orofacial oedema, furrowing of the tongue, and recurrent episodes of facial nerve palsy [1]. Due to the rarity of the disease and inconsistent presentation, MRS...

Images showing dark retinal patches information.

Deciphering dark retinal patches

3 October 2024 | Blanca Flores, Anastassios Kostakis | EYE - Vitreo-Retinal

We present a case of bilateral extensive dark without pressure (DWP) located outside the retinal vascular arcades in a young female. This retinal finding is benign but, in some instances, darkened retinal patches could be associated with potential sight-threatening conditions....

Slit-lamp photograph detail.

Dramatic myopic shift due to epithelial basement membrane dystrophy

3 October 2024 | Annes Ahmeidat, Blazej Staniszewski, James Welch | EYE - Cornea

Epithelial basement membrane dystrophy (EBMD), also known as map-dot-fingerprint dystrophy, is a common anterior corneal disorder affecting approximately 2% of the population [1]. It is characterised by the abnormal maintenance of the basement membrane, resulting in protrusions into the epithelium....

Photo of lesion from the side.

Syringocystadenoma papilliferum in the right lateral canthus

2 August 2024 | Kareem Waleed Alsaffarini, Han Xern Khoo, Egle Rostron | EYE - Pathology, EYE - Oncology

Syringocystadenoma papilliferum (SP) is an exceedingly rare, benign adnexal tumour primarily affecting the skin. It is characterised by the presence of cystic structures and papillary projections. This uncommon dermatological condition is typically found in areas rich in apocrine glands, such...

Images showing slit-lamp examination demonstrating a shallow anterior chamber and ocular coherence tomography of the anterior chamber.

Aqueous misdirection: a case series of unexpected surgical complications

3 June 2024 | Annes Ahmeidat, Caroline Cobb | EYE - Glaucoma

Aqueous misdirection (AM), also known as malignant glaucoma, is a form of secondary glaucoma that typically presents with shallowing of the anterior chamber (AC), raised intraocular pressure (IOP), and reduced visual acuity (VA) in the presence of patent peripheral iridotomies...

CT head showing dilatation of optic nerve sheath.

The challenge of chorioretinal folds in virtual eye clinics

3 June 2024 | Noorulain Khalid, Faizan Hashmi, Adam Riaz, Hadi Ziaei, Abha Gupta | EYE - Vitreo-Retinal, EYE - Orbit

Chorioretinal or choroidal folds are parallel striations involving the retina, retinal pigment epithelium (RPE), Bruch’s membrane, and inner choroid [1]. They can arise from compressive stress on these layers, and their presence often serves as a diagnostic marker for underlying...

Amsler grid drawing showing deep central scotomas of left eye.

Acute macular neuroretinopathy

3 April 2024 | Sagar Jobanputra, Marcela Bohn | EYE - Vitreo-Retinal

Acute macular neuroretinopathy (AMN) is a rare condition that typically affects young women and presents with photopsia and paracentral scotomata [1]. We describe a case of severe acute macular neuroretinopathy, following Covid-19 infection. A 30-year-old woman presented to the urgent...

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