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The pyramid
1 December 2017
| Gwyn Samuel Williams
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EYE - Cataract, EYE - Cornea, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Oncology, EYE - Orbit, EYE - Paediatrics, EYE - Pathology, EYE - Refractive, EYE - Strabismus, EYE - Vitreo-Retinal, EYE - General
The first time I attended the Congress of the Royal College of Ophthalmologists was now more than 10 years ago, though I still remember the excitement of wandering down the aisles in the exhibition hall marvelling at the stands and...
More Than Just a Call: RNIB’s Talk and Support Groups combatting loneliness
Every Thursday at 11am, something quietly powerful happens across Scotland. Phones ring, voices chime in, and a group of blind and partially sighted people connect for an hour that’s full of laughter and real talk. It’s an RNIB Talk and...Enucleation refusal for retinoblastoma
1 October 2016
| Huw Edward Oliphant
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Enucleation refusal, global survival disparity, health inequalities, retinoblastoma, treatment compliance, treatment delay
Retinoblastoma is the most common eye cancer in childhood, with enucleation rarely being the only lifesaving surgical option, especially where evidence of extraocular spread is apparent. This study sought to survey a global pool of eye care professionals with regards...
PD-1 and retinal ganglion cell death
1 February 2016
| Graham Wallace
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Apoptosis, Large retinal ganglion cells, Neuroprotection, Optic nerve crush, Programmed cell death-1
Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...
MicroRNA inhibits corneal neovascularisation
1 August 2018
| Graham Wallace
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EYE - Cornea, EYE - General
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Biomechanical stress, Corneal epithelium, MicroRNA-204, Neovascularization, VEGF, VEGFR2
MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...
The effect of everolimus on retinal pigment epithelium and proliferative vitreo-retinopathy
1 August 2018
| Kurt Spiteri Cornish
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EYE - Vitreo-Retinal
The principal cells involved in proliferative vitreo-retinopathy (PVR) are retinal pigment epithelial cells (RPE). Everolimus is a drug used in renal cell carcinoma which targets and inhibits a key regulatory protein in cancer (mTOR). In this study, the authors investigated...
Ocular adnexal marginal zone b-cell lymphoma
5 August 2020
| Jonathan Chan
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EYE - Pathology, EYE - Oncology
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conjunctiva, epidemiology, eye lids, neoplasia, orbit
This is a multicentre retrospective study of seven eye centres of 689 patients with ocular adnexal extranodal marginal zone b-cell lymphoma (OA-EMZL). The median follow-up time was 42 months and the median age was 62 years. Fifty-five percent were women;...
Online retinoblastoma surveillance tool
7 December 2020
| Annes Ahmeidat
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EYE - Pathology, EYE - Oncology
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Familial relationship, Genetics, Retinoblastoma, Surveillance
Given the vision and life-threatening course of retinoblastoma (RB), it has become a significant heritable childhood cancer to screen for. To recommend surveillance, risk must be estimated and genetic testing plays a vital role. However, genetic tests vary based on...
Second primary tumours after sebaceous carcinoma
This is a study investigating the risk of developing a second primary malignancy in patients previously diagnosed with eyelid sebaceous cell carcinoma. The records of 559 patients who were diagnosed with sebaceous cell carcinoma between 2000 and 2016 were reviewed,...Using a tumour registry to investigate optic nerve gliomas
31 October 2023
| Lauren R Hepworth
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EYE - Neuro-ophthalmology
This study is a retrospective comparative analysis. Patients with optic nerve glioma and pilocytic astrocytoma were identified through the Surveillance, Epidemiology and End Results (SEER) cancer registry covering a 42-year period using standardised codes. The following data was extracted: basic...
Caring for adults with an ocular tumour
1 December 2015
| Bertil E Damato
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EYE - Vitreo-Retinal
Detection If you screen for an intraocular tumour, dilate the pupil. If the patient is driving, use phenylephrine only. If the patient declines, document this in the casenotes. Don’t forget to look for sentinel vessels, which would indicate a ciliary...
Part 1: Good news, bad news at the international conference
3 June 2024
| Peter Cackett
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EYE - General
One of my favourite comic strips from my childhood was Good News, Bad News which ran in Jackpot comic from 1979–1982. In this strip, the story for the main character would be described in a series of alternating ‘Good News’...