Journal Reviews
Optimal timing for idiopathic ERM peeling based on pre-op visual acuity threshold
This single-centre retrospective study aimed to evaluate the efficacy and safety of vitrectomy-peeling for idiopathic epiretinal membrane (iERM) in patients with preserved preoperative best-corrected visual acuity (BCVA) compared to those with reduced BCVA, to determine the optimal preoperative VA threshold...
Risk of non-infectious uveitis associated with medications for substance use disorders
The authors evaluate the risk of non-infectious uveitis (NIU) in patients prescribed medications for medication-assisted treatment (MAT) of substance use disorders compared to a control group prescribed selective serotonin reuptake inhibitors (SSRIs). Utilising aggregated electronic health record data, this retrospective...
Predictive value of OCT biomarkers on visual outcome in retinal vein occlusion
This was a retrospective study. The cohort included 163 eyes from patients diagnosed with retinal vein occlusion (RVO) aged 18 years or older. The primary endpoints were the mean change in best corrected visual acuity (BCVA) at baseline to follow-up...
The evolving landscape of diabetic retinopathy
This article outlines efforts to modernise clinically meaningful staging systems and endpoints for diabetic retinal disease (DRD). During a workshop involving over 100 international experts, participants emphasised the need for validated structural and functional endpoints based on the retinal neurovascular...
Limitations of next generation sequencing
This is a report of a young female patient with clinically diagnosed retinitis pigmentosa who underwent genetic testing using an inherited retinal disease panel and whole exome sequencing by next generation sequencing (NGS) technology. This approach did not identify any...
Healthcare costs of early vs late genetic testing
This is a retrospective observational cohort study of the relative healthcare costs incurred by early vs late genetic testing for inherited retinal diseases in a population of patients from the USA. Three hundred and ten patients with a genetically confirmed...
Elevated anxiety levels in central serous chorioretinopathy
This prospective cross-sectional case-control, questionnaire-based study was aimed to compare association of anxiety disorder in patients with central serous chorioretinopathy (CSCR) and age-gender-matched healthy controls. Participants in the age group of 18–55 years were divided into 2 groups. Group A...
Open globe trauma – visual outcomes after primary vitrectomy
This retrospective study aimed to evaluate the impact of early vitrectomy on visual outcomes in eyes with open globe ocular trauma. One hundred and eighty eyes from a cohort of 166 patients who underwent primary vitrectomy between 2017 and 2023...
Reclassifying genetic variants in inherited retinal diseases
The authors present a retrospective study of 142 gene sequence variants from 28 patients with vitreoretinal dystrophies which were re-interpreted based on American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP) guidelines. Overall, there was...
Clinical characteristics and visual outcome of patients with macular pseudohole
This is a retrospective study of consecutive patients with macular pseudohole (MPH) who had vitrectomy and were followed for at least 6 months postoperatively. MPH was diagnosed based on spectral-domain optical coherence tomography (OCT) findings. 76 eyes of 75 patients...
Patient perspectives on inherited retinal diseases
The authors present a qualitative study of patient perspectives on living with inherited retinal diseases based on social media engagement. Social media posts from 6 sites were analysed over a 10-year period. Data was extracted manually by the research team,...
Comparison of the efficacy of anti-VEGFs agents in nvAMD
This retrospective multicentric study conducted in Israel and Canada, compared the efficacy of bevacizumab, aflibercept 2mg and ranibizumab as first-line treatments for neovascular age-related macular degeneration (nvAMD). Included were treatment-naïve nvAMD eyes receiving ≥12 months of treat-and-extend (T&E) anti-VEGF therapy...
