Journal Reviews
Incidental ocular surface squamous neoplasia in pterygia: a systematic review and meta-analysis
This is a systematic review of 12 papers, which included 8688 participants and identified 202 cases of incidental ocular surface squamous neoplasia (OSSN) (pooled prevalence=1.32%, 95% confidence interval (CI), I2=95.3%). Meta-regression showed that lower OSSN prevalence was associated with greater...
Understanding the extracellular matrix in uveal melanoma
This review examines how the extracellular matrix (ECM) is remodelled throughout uveal melanoma development, from the eye to the liver. Uveal melanoma, the most common primary intraocular malignancy in adults, carries a poor prognosis due to its propensity for hepatic...
Early biomarker for paraneoplastic retinopathy
This informative case series evaluates 4 eyes of 2 patients presenting with rapidly progressive vision loss secondary to cancer-associated retinopathy. The authors identified a distinct spectral-domain optical coherence tomography structural feature termed the angular sign of Henle fibre layer hyperreflectivity...
Effect of intra-arterial chemotherapy drug regimens on globe salvage outcomes of retinoblastoma patients
This is a retrospective study from Shandong University, China, between May 2016 to November 2019, to compare the effect of 3-drug regimen (melphalan (MP) , topotecan (TP) and Carboplatin (CP)) of 95 patients (97 eyes) with two-drug regimen (MP and...
Vitreoretinal lymphoma: The importance of cerebral spinal fluid evaluation at initial diagnosis
This is a retrospective single centre case observational study between 2006 and 2024 at Memorial Sloan Kettering Cancer Center, to review patients with biopsy-proven central nervous system lymphoma and MRI brain evaluation. Sixth-five patients were included in this study, 11...
Long-term incidence and survival trends in retinoblastoma in the USA
The authors present a retrospective observational study of 5730 patients diagnosed with retinoblastoma between 1996 and 2018. Data on demographics, age at diagnosis, treatment and survival were extracted from national registries with coverage of 99% of the population of the...
Epidemiology of ocular cancer in Cali
The aim of this study was to describe the population trends of incidence and survival rates of ocular cancer in Cali, Columbia. Data was retrieved from the Registro Poblacion de Cancer de Cali (RPCC, i.e. Population Cancer Registry of Cali)...
Ten-year experience with intracameral chemotherapy for aqueous seeding in retinoblastoma: long-term efficacy, safety and toxicity
This is a retrospective review of all consecutive patients with primary (n=4) or secondary non-iatrogenic (n=16) aqueous seeding (AS) treated by intracameral chemotherapy (ICC) in Lausanne between 2011 and 2020 with a minimum follow-up of one year. Aqueous seeding control...
Retinoblastoma mortality associations with choroidal and optic nerve invasion
The authors present a retrospective cohort study. Data was extracted from the National Cancer Institute’s Surveillance Epidemiology and End Results (SEER) database, based in the US and founded in 1973. Cases of retinoblastoma were extracted using the inclusion criteria of...
Histopathology-guided management of ocular surface squamous neoplasia (OSSN) with corneal stromal or scleral invasion using ruthenium-106 plaque brachytherapy
This is a retrospective interventional consecutive case series of 42 eyes of 42 patients with OSSN with histopathologically proven corneal stromal and / or scleral invasion following excision biopsy. The mean tumour basal diameter was 9.3mm and thickness of 3.1mm...
Germline testing for uveal melanoma
The authors present a study of 114 consecutive patients presenting with uveal melanoma. Between 1 December 2019 and 1 November 2021 all patients over 18-years-old presenting to their centre with uveal melanoma were offered germline testing for variants in BAP1,...
Cutaneous malignant melanoma metastasis to pseudophakic lens
Metastases to the eye and orbit are rare and intraocular cutaneous malignant melanoma metastasis (ICMM) is exceedingly rare, representing around 5%. There have only been three previous cases of ICMM to the lens in the literature, all of which presented...
