Journal Reviews

British Journal of Ophthalmology Feb 2020 cover image

Episcleral brachytherapy (EB) for retinoblastoma (RB)

5 June 2020 | | Ocular Pathology and Oncology | episcleral brachytherapy, focal consolidation therapy, ocular survival, recurrence-free survival, retinoblastoma

This retrospective study consisted of 11 eyes treated either with Iodine (I) -125 or Ruthenium (R) -106EB with a mean apical dose of 44Gy. There were five in group B (46%), three in group C (27%) and three in group...

Ophthalmic Epidemiology cover picture

Paediatric enucleation in a tertiary eye centre in North China, 2001-2015

2 December 2019 | | Paediatric Ophthalmology / Strabismus | Enucleation, evisceration, ocular trauma, pediatric, retinoblastoma

The authors review the demography and aetiology of paediatric enucleation over a 15-year period. A total of 9307 paediatric ophthalmic inpatients ranging from 0 to 14 years who underwent surgery at Shandong Eye Institute over the past 15 years were...

Complications with porous orbital implant after enucleation in retinoblastoma patients

1 April 2019 | | Orbit | Chemotherapy, complications, exposure, porous implant, retinoblastoma

This is a retrospective, case control study aimed to identify risk factors associated with complications in retinoblastoma patients following primary and secondary enucleations with porous implant placements. Patients with retinoblastoma who underwent enucleation with porous orbital implant placement between January...

Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells

1 October 2016 | | Retina / Uvea / Vitreous | chemotherapy, intra-ocular tumour, retinal pigment epithelium, retinoblastoma, toxicity

There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...

Enucleation refusal for retinoblastoma

1 October 2016 | | Enucleation refusal, global survival disparity, health inequalities, retinoblastoma, treatment compliance, treatment delay

Retinoblastoma is the most common eye cancer in childhood, with enucleation rarely being the only lifesaving surgical option, especially where evidence of extraocular spread is apparent. This study sought to survey a global pool of eye care professionals with regards...

Long-term outcomes for hereditary retinoblastoma

1 December 2014 | | Paediatric Ophthalmology / Strabismus | chemotherapy, failure rate, focal therapy, hereditary retinoblastoma, visual acuity

Earlier diagnosis and more rigorous treatment regimens have contributed to better outcomes for patients with retinoblastoma. This study looked at 24 patients with hereditary bilateral retinoblastoma treated with systemic chemotherapy during a ten year period (2001-2011). The medical notes were...

MicroRNA mediate retinoblastoma signal transduction

1 October 2014 | | Retina / Uvea / Vitreous | KEGG, cell migration, colony formation, microRNA-21, phosphorylation signaling pathway, retinoblastoma, seed-targeting, tiny anti-miRNA

MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...