Journal Reviews
Two-year GATHER2 data: anatomical gains, functional questions for avacincaptad pegol in geographic atrophy
Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) remains a leading cause of irreversible central vision loss, and complement dysregulation has long been implicated in its pathogenesis. In 2023, the US FDA approved the first two GA therapies, both...
Seeing mitochondrial disease
This review highlights mitochondrial diseases as the most common inherited neurometabolic disorders, often affecting multiple high-energy organs, with eye involvement frequently representing the earliest or predominant feature. Diagnosis is challenging due to significant genetic and clinical heterogeneity, including variable expressivity,...
Healthcare access gaps in adults with vision difficulty
The authors analyse data from the Behavioral Risk Factor Surveillance System (2019–2021) to evaluate disparities in healthcare access among adults with self-reported vision difficulty. This large cross-sectional study demonstrates that individuals reporting visual impairment face significant barriers across multiple domains...
Perspectives on sustainability in ophthalmology
This was a prospective study of a multi-item survey aimed to assess and analyse patients’ perception of sustainability and the role of healthcare in general, and ophthalmology in particular. Levels of agreement were measured using a Likert scale. 105 patients...
Impact of the Covid-19 pandemic on ophthalmology conferences
The Covid-19 pandemic encouraged the transition to telehealth and virtual platforms in ophthalmology conferences. This cross-sectional study analysed data from five US-based ophthalmology conference organisations. Conference meetings were categorised as in-person, virtual or hybrid. Data included total attendance, trainee participation,...
Bardet Biedl refractive error
This is a retrospective cross-sectional study of 45 patients with genetically diagnosed Bardet Biedl syndrome. Patients with biallelic defects in any gene known to cause Bardet Biedl syndrome were eligible for inclusion. Patients underwent cycloplegic refraction and keratometry. The mean...
Retrospective analysis on the outcomes of contact lens-associated keratitis in a tertiary centre
This is a retrospective cohort study of 161 eyes (153 patients) with contact lens-associated keratitis (CLAK) from Moorfields Hospital between 1 July 2021 to 28 February 2022. They were classified into three groups based on the size of the epithelial...
Repeat corneal collagen cross-linking after failure of primary cross-linking (CXL) in keratoconus
This is a 10-year, retrospective, patients record review from Leeds, UK. Twenty-one eyes had repeated CXL and the mean interval between primary and repeat CXL was 47.1 months. Twenty (95%) eyes stabilised after repeated CXL at a mean follow-up of...
Long-term outcomes of deep anterior lamellar versus penetrating keratoplasty for keratoconus
This is a retrospective consecutive and comparative case series of keratoplasties (228 deep anterior lamellar keratoplasties (DALKs) and 274 penetrating keratoplasties (PKs)) in a single centre by one surgeon in France, between 1993 and 2021. Graft survival was 96.7% at...
Neurogenic palsy due to COVID-19
The authors aimed to identify cases of neurogenic palsy in the presence of Covid-19 and document the patient characteristics, type of palsy and possible aetiologies. Case reports and case series were included in the search. Twenty-three articles were included with...
Microsporidia-induced stromal keratitis: a new cause of presumed immune stromal (interstitial) keratitis
This is a non-comparative retrospective observational case series from India from 1 October 2020 to 31 January 2021. The inclusion criteria were: (1) presence of nummular / coin shaped lesions with at least one >2mm in size and / presence...
