Journal Reviews

Environmental variations in endophthalmitis

3 August 2023 | | EYE - Vitreo-Retinal | Endophthalmitis, anti-VEGF, climate, intravitreal injection, season

In this retrospective cohort study, the authors looked at seasonal and environmental variations in 171 endophthalmitis cases out of 423,297 intravitreal injections. The incidence of this complication was not correlated to monthly snowfall, rainfall, or average temperature. There was no...

Ophthalmologica journal cover image.

Intravitreal dexamethasone in diabetic macular oedema (DMO) - enhancing the response to anti-VEGF in non- or poor responders

3 February 2023 | | EYE - Vitreo-Retinal | Aflibercept, Anti-VEGF, Dexamethasone implant, Diabetic macular oedema, Persistent, Ranibizumab, Resistant

This study aimed to describe the outcomes of a switch back from DEXi (dexamethasone implant) to anti-VEGF therapy in eyes that were treated temporarily with DEXi after an initial poor response to anti VEGF. Twenty-three eyes of 17 patients were...

Ophthalmologica journal cover image.

Progression of macular atrophy on long-term anti-VEGF therapy for AMD

3 October 2022 | | EYE - Vitreo-Retinal | Anti-VEGF therapy, Long term, Macular atrophy, neovascular age-related macular degeneration

This retrospective study evaluated the progression of macular atrophy in 53 eyes of 53 patients receiving AntiVEGF Therapy for age-related macular degeneration (nAMD), for at least six years. None of the patients had any macular atrophy (MA) at presentation. MA...

MicroRNA inhibits corneal neovascularisation

1 August 2018 | | EYE - Cornea, EYE - General | Biomechanical stress, Corneal epithelium, MicroRNA-204, Neovascularization, VEGF, VEGFR2

MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...

Management of diabetic macular oedema (DMO)

1 February 2018 | | EYE - Vitreo-Retinal | Anti-VEGF therapy, Diabetic macular edema, Steroids

The authors present guidelines on current diagnostic and therapeutic procedures in the management of DMO. Fluorescein angiography (FA) and optical coherence tomography (OCT) are recommended before starting treatment to help diagnose and stage DMO, and can be repeated if there...

High dose (2.5mg) bevacizumab for postradiation cystoid macular oedema

1 April 2017 | | EYE - Pathology, EYE - Oncology | Anti-VEGF, Cystoid macular edema, Melanoma, Radiation damage, Radiotherapy, Tumor

The authors present a retrospective, interventional case series investigating the efficacy of high dose (2.5mg/0.1ml) intravitreal bevacizumab in the treatment of persistent postradiation (Iodine-125 plaque brachytherapy for uveal melanoma) cystoid macular oedema (CME). Persistent CME was defined as increased or...