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Exploiting nature’s randomised trials of eye disease

1 December 2022 | | EYE - Glaucoma, EYE - Vitreo-Retinal, EYE - Orbit
Confounding and reverse causation in observational ophthalmic epidemiology Traditional observational studies are inherently limited in establishing a causal effect of an exposure on an outcome of interest. One fundamental limitation is confounding, whereby causation is incorrectly attributed to a third...

My Top Five: Promising gene therapies for ocular conditions

4 December 2024 | | EYE - Vitreo-Retinal
Gene therapy, a pivotal advancement in modern medicine, particularly shines in ophthalmology. By targeting defective genes with engineered vectors, this approach promises significant strides in treating inherited retinal diseases. This article reviews the top five gene therapies in late-stage trials,...

My Top Five: Promising gene therapies for ocular conditions

4 December 2024 | | EYE - Vitreo-Retinal
Gene therapy, a pivotal advancement in modern medicine, particularly shines in ophthalmology. By targeting defective genes with engineered vectors, this approach promises significant strides in treating inherited retinal diseases. This article reviews the top five gene therapies in late-stage trials,...

Treatment of diabetic macular oedema

1 June 2014 | | EYE - Vitreo-Retinal
Diabetic macular oedema (DMO) is a common complication associated with diabetic retinopathy, and the most common cause of visual impairment in diabetes [1]. With predicted rising levels of diabetes (in England by 2025 the estimated population with diabetes will be...

Childhood glaucoma

2 October 2025 | | EYE - Paediatrics, EYE - Glaucoma
When a child is given a diagnosis of glaucoma, the impact upon that child and their family is enormous; equivalent to the diagnosis of a cancer [14]. This previously published article (2019) outlines the knowledge, techniques and approaches that offer...

Progress in retinal disease management: Highlights of the Retina Day, RCOphth 2025 Annual Congress

4 August 2025 | | EYE - Vitreo-Retinal
The Retina Day meeting at the Royal College of Ophthalmologists (RCOphth) 2025 Annual Congress in Liverpool was held on 22 May 2025. This report highlights 10 selected topics of interest to subspecialists and general ophthalmologists. Decarbonising anti-VEGF clinics (or making...

Glaucoma care provision using a multidisciplinary approach: a personal view

1 February 2018 | | EYE - Glaucoma, EYE - General
This article is going to explain the secret to running an efficient multidisciplinary glaucoma service which will comfortably meet the demands of an ever-growing elderly population, within the confines of budgetary and clinical constraints, wherever the setting. This may be...

Ultrasound biomicroscopy (part 2): primary angle closure

1 December 2016 | | EYE - Glaucoma, EYE - Imaging
Patients with primary angle closure or primary angle closure glaucoma [PAC(G)] comprise a significant subgroup affecting around 10% of glaucoma patients amongst Caucasians. Assessment of the patient with angle closure, or narrow angles, requires gonioscopy. However, whilst identifying the presence...

The results of the last survey Jun24

3 June 2024 | | EYE - Cataract, EYE - Refractive
When I was in my training and even in my early years as a consultant, I did not fully understand the difference between different lenses. When asked my preference of hydrophilic versus hydrophobic intraocular lenses (IOLs) I really did not...

Recurrent corneal erosions secondary to isotretinoin use

7 December 2020 | | EYE - Cornea, EYE - Glaucoma
Isotretinoin (13–cis-retinoic acid) is the first line treatment for moderate to severe nodulocystic or papulopustular acne [1,2]. Although it is a safe medication, it has several adverse side-effects, including ophthalmic manifestations, as shown in Table 1 [3]. These side-effects need...

Diabetes macular oedema in pregnancy self-resolving postpartum

1 October 2021 | | EYE - Vitreo-Retinal, EYE - Imaging, EYE - General
*Equally contributing co-first authors. Diabetic macular oedema (DMO) is a common clinical presentation to ophthalmology clinics. Ample evidence exists for management of DMO in non-pregnant patients. However, there is a paucity of evidence on the optimal management of DMO in...

In vivo confocal microscopy, principles and use in keratitis Part 1: Principles

1 April 2018 | | EYE - Cornea, EYE - Imaging
In 1968 Maurice introduced the concept of high powered specular microscopy, it was in that very year that the first scanning confocal microscope was proposed. Marvin Minsky developed the first confocal microscope in 1955 named the ‘double focusing scanning microscope’....