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Clinical & Experimental Ophthalmology journal cover image.

Genetic analysis of choroideremia families

1 February 2016 | | EYE - Vitreo-Retinal
Choroideremia (CHM) is a rare X linked recessive chorioretinal dystrophy. Symptoms include nyctalopia and progressive peripheral field loss. Female carriers may have mild symptoms. Choroideremia is known to be caused by a mutation in the CHM gene. A multicentre human...
Ophthalmic Plastic and Reconstructive Surgery journal front cover image.

Diagnosis and management of orbital vascular malformations

1 August 2014 | | EYE - Oculoplastic, EYE - Orbit
This is an authoritative review of a controversial and difficult clinical area. The authors have experience of over 350 cases and provide a well-structured review of the classification and management of orbital vascular malformations. They emphasise the need to understand...
Experimental Eye Research cover image.

HtrA1 enhances cell senescence

1 December 2013 | | EYE - Vitreo-Retinal
A genetic basis for age-related macular degeneration (AMD) has been greatly advanced in recent years. The role of identified pathways such as complement factor H in AMD has been widely investigated. However, the effect of other gene variants identified by...

100 years of insulin

3 October 2022
*Joint first authors The centenary of the discovery of insulin is a time to celebrate one of the most significant scientific discoveries of the 20th century. Background Before 1923, Type 1 diabetes mellitus [T1DM] resulted in death from severe ketoacidosis...

Leveraging networks and collaboration: The Calabar Diabetic Retinopathy Service, from inception to a state-wide service, research and training hub

3 June 2026 | | EYE - Vitreo-Retinal, EYE - Imaging
Diabetic retinopathy (DR), a microvascular complication of diabetes mellitus (DM), is a leading cause of preventable vision loss and blindness in people of working age globally [1]. Diabetic retinopathy is a disease of public health importance in Nigeria as it...

Orbital airgun pellet injuries: A paediatric case pair

10 December 2025 | | EYE - Orbit, EYE - Paediatrics
Airgun injuries to the eye and orbit can be visually devastating. The pellet need not impact the globe directly to cause visual loss, as the cone shaped orbit may funnel the projectile into the orbital apex and optic nerve. We...

SOS (Simplified Ophthalmic Statistics) Part 3: Which statistical test should I use (if any)?

4 December 2018 | | EYE - General
P<0.05 is a statement that brings joy to many researchers. Arguably this is because inclusion of such a statement may increase the chance of acceptance for publication. Whilst statisticians and non-statisticians are united in trying to change this culture, cultural...

Case series of toxic anterior segment syndrome

1 August 2019 | | EYE - Cataract, EYE - Refractive, EYE - General
Herein we report two cases of toxic anterior segment syndrome (TASS) following uneventful cataract surgery. Both patients presented 24 hours after their uneventful operations with painless blurred vision in the operated eye. The inflammatory reaction was controlled successfully with an...

Personalising the management of dry eye disease: TFOS DEWS III updates evidence-based recommendations

11 June 2026 | | EYE - Cornea, EYE - Oncology
Dry eye disease (DED) is a heterogenous condition that arises from various aetiologic factors and leads to tear film instability, ocular surface damage and neurosensory changes. Symptoms of DED include ocular dryness, burning, itching, pain and visual impairment. An evidence-based...

Eye lid lesion

1 April 2014 | | EYE - Cataract, EYE - Cornea, EYE - General, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Oncology, EYE - Orbit, EYE - Paediatrics, EYE - Pathology, EYE - Refractive, EYE - Strabismus, EYE - Vitreo-Retinal
A 46-year-old female farmer was referred by her local GP to the eye department with a history of gradually increasing upper eyelid lesion over 10 weeks, despite the patient being treated with topical and oral antibiotics. The patient was a...

Retinoblastoma management update (part 1): clinical features, diagnosis and genetics

1 January 2017 | | EYE - Oncology
The first of a two part series, this article will discuss the clinical features, diagnosis and genetic aspects of retinoblastoma. Manoj Parulekar is based at Birmingham Children’s Hospital, one of the two designated national retinoblastoma and paediatric ocular oncology treatment...

Are we short-sighted about myopia?

1 December 2017 | | EYE - Cataract, EYE - Refractive, EYE - General
Worldwide prevalence of myopia has increased rapidly in recent years and has now reached epidemic levels, particularly in South-East Asia where prevalence is around 80% [1-4]. Myopia prevalence is also increasing in the United States and Europe where it is...