Journal Reviews archive for 2016
PD-1 and retinal ganglion cell death
Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...
Differential inhibition of EAU by CTLA4 and IL-6
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...
Limbal melanocytes and the stem cell niche
The cornea is continually regenerated to maintain clear vision, due to a population of stem cells located in the limbal region between the cornea and the conjunctiva. These limbal stem cells (LESC) reside in crypts in structures called the Pallisades...
Sex differences in the relationship between obesity and choroidal nevus in US adults
The National Health and Nutrition Examination Survey (NHANES); a population-based survey conducted annually in the US by the Centers for Disease Control and Prevention, was used to identify populations at higher risk for choroidal naevus. Over a period of four...
Subthreshold micropulse laser treatment in chronic central serous chorioretinopathy
This retrospective study was conducted to assess the treatment of 38 patients of chronic central serous chorioretinopathy with a 577-nm subthreshold micropulse laser (SML) Supra Scan Quantel Medical. Eighteen patients of these had persistent subretinal fluid (SRF) after photodynamic therapy....
