Journal Reviews

Differential inhibition of EAU by CTLA4 and IL-6

1 February 2016 | | Retina / Uvea / Vitreous | Biologic, CTLA4, Cytokine, Experimental autoimmune uveitis, T cell, Uveitis

Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...