Differences in elastometry of cornea and optic nerve head in both eyes of patients with NAION
1 February 2019
| Claire Howard
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EYE - Neuro-ophthalmology
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Corneal hysteresis, corneal resistance factor, non-arteritic anterior ischaemic neuropathy, optic nerve head biomechanics, real-time elastography
Non-arteritic anterior ischaemic optic neuropathy (NAION) is an important cause of visual loss in the middle aged and elderly population. This prospective cross-sectional study investigates the biomechanical properties of optic nerve head (ONH) and cornea in both eyes of patients...
MicroRNA inhibits corneal neovascularisation
1 August 2018
| Graham Wallace
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EYE - Cornea, EYE - General
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Biomechanical stress, Corneal epithelium, MicroRNA-204, Neovascularization, VEGF, VEGFR2
MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...
Corneal stroma modelling under hypoxic conditions
1 August 2018
| Graham Wallace
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EYE - Cornea, EYE - General
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Confocal fluorescence microscopy, Cornea, Corneal organ culture, Extracellular matrix, Stroma
The cornea is exposed to hypoxia under several conditions including sleep, inflammation and wound healing. Being an avascular tissue to maintain transparency, how the cornea homeostatic controls oxygen tension is important. To address this process two models were utilised; a...
Treatment of severe chronic ocular graft-versus-host disease
1 February 2018
| Jonathan Chan
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EYE - Cornea, EYE - General
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Cornea, Inflammation, Treatment Medical, Wound healing
A retrospective study from Cologne, Germany, between November 2012 to March 2015, of 17 patients with graft-versus-host disease (GVHD) treated with 100% single use vials autologous serum eye drops in sealed system. Visual acuity, corneal staining, frequency of artificial tears,...
Clinical outcomes of AMT in acute ocular chemical injury
1 August 2017
| Jonathan Chan
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EYE - Cornea, EYE - General
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Cornea, Inflammation, Ocular surface, Stem Cells, Treatment Surgery
This is a retrospective study of patients from two units in Germany and UK between 1998 and 2008. The ocular chemical burns were classified by Roper-Hall and Dua classifications. A total of 72 eyes of 54 patients aged 37.3 years...
Stromal cell alignment in damaged cornea
1 August 2017
| Graham Wallace
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EYE - Cornea, EYE - General
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Confocal microscopy, Corneal wound healing, Extracellular matrix, SHG imaging
Stromal keratocytes are responsible for wound healing in the cornea following damage. Keratocytes at the site of injury become activated and differentiate to myofibroblasts which secrete extracellular matrix (ECM) to close the wound, a response mediated by transforming growth factor...
C-spp corneal consequences
This is a retrospective review of microbiological records of 22 patients, who had presented at the LV Prasad Eye Institute, India, between June 2009 and December 2012. The corneal scrapings were performed in all patients and had yielded significant growth...
Secondary iris-claw anterior chamber lens implantation in patients with aphakia without capsular support
1 August 2014
| Jonathan Chan
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EYE - Cataract, EYE - Refractive
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Anterior chamber, Cornea, Lens and zonules, Optics and Refraction, Treatment Surgery
This retrospective, non-randomised, non-comparative, interventional study including 128 eyes of 124 patients that presented with aphakia with no capsular support. All patients consecutively underwent Artisan iris-claw intraocular lense (IOL) implantation between 1997 and 2010. The inclusion criteria were: aphakic without...
