Journal Reviews

Differential inhibition of EAU by CTLA4 and IL-6

1 February 2016 | | Retina / Uvea / Vitreous | Biologic, CTLA4, Cytokine, Experimental autoimmune uveitis, T cell, Uveitis

Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...

γδ T cell depletion does not affect fungal keratitis

1 August 2015 | | Cornea / External Eye Disease | CFW, Cytokines, FK, Fungal keratitis, IL-17, Neutrophils, calcofluor WHITE, fungal keratitis, γδ T cells

Fungal keratitis (FK) is a blinding condition prevalent in agricultural areas of countries such as India and China. The fungus enters the cornea and induces an inflammatory response which leads to tissue damage. Neutrophils are the earliest infiltrating immune cells...