Journal Reviews
Mydrin-P microdrops vs mydrin-P standard drops for ROP examination
This was a non-inferiority prospective randomised controlled trial to compare efficacy and safety of microdrops over standard dose mydrin-P in retinopathy of prematurity (ROP) screening, and to determine optimal time for eye examination after administration of drops. The trial included...
Outcomes for symptomatic esophoria with or without prism adaptation test
The authors aimed to compare the frequency of repeated interventions between patients who had prism adaptation test (PAT) and conventional orthoptic measurements, and those that did not, in order to measure changes in angle after PAT and surgical outcome. This...
Comparison of the efficacy of anti-VEGFs agents in nvAMD
This retrospective multicentric study conducted in Israel and Canada, compared the efficacy of bevacizumab, aflibercept 2mg and ranibizumab as first-line treatments for neovascular age-related macular degeneration (nvAMD). Included were treatment-naïve nvAMD eyes receiving ≥12 months of treat-and-extend (T&E) anti-VEGF therapy...
Investigation of PAX7 positive satellite cells in extraocular muscle surgery
PAX7 is a transcription factor and is expressed in non-active and activated satellite cells. It is needed for muscle progenitor function, survival and expansion. This study investigates the effect of recession/resection surgery on PAX7-positive satellite cells in extraocular muscles of...
Outcome of surgery for infantile exotropia after long-term follow-up of 4 years
The purpose of this study was to report long-term motor and sensory outcomes after unilateral lateral/medial rectus recession/resection (RR) in infantile constant exotropia. This was a retrospective review from 1995–2020 of 20 children (10 female, 10 male) with minimum 4-year...
How do immediate and sequential bilateral cataract surgery compare?
The authors present a retrospective cohort study with the aim of comparing the outcomes and complications of immediate sequential bilateral cataract surgery (ISBCS) and delayed sequential bilateral cataract surgery (DSBCS). Children (aged 0–24 months) undergoing bilateral cataract surgery at a...
Keratoconus prevalence in astigmatic adolescents
The authors from Israel performed a cross-sectional study of 896,377 adolescents aged 16–20 years who underwent refraction and topography/tomography between 2011 and 2022. A total of 1886 (0.21%) were diagnosed with keratoconus with increasing astigmatism level being strongly associated with...
Pneumatic trabeculectomy
The authors present a novel technique which uses constant pressure air infusion via the constellation vision system (Alcon Laboratories) to prevent anterior chamber (AC) collapse and intraocular pressure fluctuations during trabeculectomy in high-risk cases. This was a prospective, interventional, non-randomised,...
Prognosis of ocular motor cranial nerve palsies caused by pituitary adenoma and meningioma
The authors present a retrospective cohort study with the aim of comparing recovery rate and time of ocular motor cranial nerve palsies (CNP) caused by pituitary adenoma or meningioma. Cases were identified from a single tertiary referral centre over a...
Biomarkers in thyroid eye disease
An ideal biomarker is sensitive, specific, easily assessable and clinically relevant. This study looked at the presence of inflammatory cytokines present in the tear film of healthy controls, thyroid patients without eye disease (non-TED) and those with thyroid eye disease...
Immunotherapy for orbital SCC
In the UK, cemiplimab is recommended for treating metastatic or locally advanced cutaneous squamous cell carcinoma (SCC) in adults when curative surgery or curative radiotherapy is not suitable. Pembrolizumab is recommended as an option for untreated metastatic or unresectable recurrent...
Diagnostic yield of routine metastatic work-up in conjunctival melanoma
Conjunctival melanoma (CM) is a rare but potentially aggressive malignancy of the ocular surface with high rates of local recurrence and metastasis. Eighty-one consecutive patients with invasive conjunctival melanoma treated by the senior author over the course of 23 years...
