Journal Reviews
Opening the AI ‘black box’ for glaucoma
Artificial intelligence (AI) models show great promise for glaucoma detection using retinal images, but their ‘black box’ nature is a major barrier to clinical adoption. Clinicians are often hesitant to trust a diagnosis without understanding its reasoning. This paper provides...
Low-dose bimatoprost/timolol gel: a new fixed-combination option
This phase III international randomised trial evaluated the efficacy and safety of a new low concentration bimatoprost/timolol eye gel (bimatoprost 0.01%/timolol 0.1%). It was compared with the conventional higher-strength fixed combination eye drops (bimatoprost 0.03%/timolol 0.5%) in patients with open-angle...
Selective laser trabeculoplasty after medical treatment
Selective laser trabeculoplasty (SLT) is a well-established treatment for open-angle glaucoma (OAG) and ocular hypertension (OHT). This post-hoc secondary analysis of the LiGHT trial extension examined SLT as a secondary intervention after 3 years of protocolised medical therapy in patients...
Risk of fractures with glaucoma
In this systematic review and meta-analysis, 7 articles were analysed, with 570,694 subjects and a reported total of 45,957 fractures. The study protocol (CRD42024527785) was registered prospectively. PubMed, EMBASE, and Web of Science were searched from their inception to April...
Clinical outcomes following intraluminal stent removal from the PAUL glaucoma implant
This single German centre retrospective cohort study included 70 eyes from 68 patients. Qualified and complete success rates (95% CI) were 92.9% and 55.7% after 1 year and 88.6% (81.4–95.7%) and 50% (37.1–62.9%) at the last follow-up time point for...
Understanding optic nerve head pericytes and glaucoma
The authors provide a comprehensive review of the current understanding of pericytes in the optic nerve head (ONH). Key points include: (1) Pericytes are contractile mural cells that play crucial roles in regulating blood flow, maintaining the blood-brain / blood-retinal...
Feasibility and acceptability of virtual reality visual field testing compared to standard perimetry
The authors present a prospective pilot study which aimed to assess the feasibility and performance of the vivid vision perimeter (VVP). The VVP is a piece of software which can be used with off-the-shelf virtual reality (VR) headsets. Recruitment took...
Transcriptomic and regulatory gene associations in open angle glaucoma
The authors report a study utilising a publicly available whole exome sequencing dataset of 28 patients with primary open angle glaucoma (POAG) and seven healthy control patients, and a transcriptomic dataset from the trabecular meshwork of four POAG patients and...
Long-term outcomes after acute primary angle closure
This is a retrospective observational study including 121 eyes of 117 consecutive patients with acute primary angle closure (APAC) over a four-year period, between 1 January 2010 to 31 December 2014. Seventy-three percent had achieved visual acuities of ≥ 6/12,...
Under pressure: the constant drive to improve IOP monitoring
The authors offer a comprehensive overview of interplay between glaucoma and intraocular pressure (IOP), IOP measurement principles and historical measurement techniques and progress in IOP measurement devices. The authors explore the issues surrounding current thinking in IOP measurement and its...
A novel parameter for angle closure
This is a population cross-sectional study of 464 eyes that underwent swept-source optical coherence tomography (SSOCT) imaging in the dark. Eight out of 128 cross-sectional images were selected for analysis. Matlab was used to measure the iridolenticular contact area (ILCA),...
Variability between handheld fundus cameras
Handheld fundus cameras offer the potential of enhancing opportunities for telemedicine diagnosis of glaucoma, especially in underserved settings, as they are less bulky, inexpensive and don’t require skilled personnel compared to traditional table-mounted retinal cameras. This study aimed to compare...
