Journal Reviews
Understanding optic nerve head pericytes and glaucoma
The authors provide a comprehensive review of the current understanding of pericytes in the optic nerve head (ONH). Key points include: (1) Pericytes are contractile mural cells that play crucial roles in regulating blood flow, maintaining the blood-brain / blood-retinal...
Feasibility and acceptability of virtual reality visual field testing compared to standard perimetry
The authors present a prospective pilot study which aimed to assess the feasibility and performance of the vivid vision perimeter (VVP). The VVP is a piece of software which can be used with off-the-shelf virtual reality (VR) headsets. Recruitment took...
Transcriptomic and regulatory gene associations in open angle glaucoma
The authors report a study utilising a publicly available whole exome sequencing dataset of 28 patients with primary open angle glaucoma (POAG) and seven healthy control patients, and a transcriptomic dataset from the trabecular meshwork of four POAG patients and...
Long-term outcomes after acute primary angle closure
This is a retrospective observational study including 121 eyes of 117 consecutive patients with acute primary angle closure (APAC) over a four-year period, between 1 January 2010 to 31 December 2014. Seventy-three percent had achieved visual acuities of ≥ 6/12,...
Under pressure: the constant drive to improve IOP monitoring
The authors offer a comprehensive overview of interplay between glaucoma and intraocular pressure (IOP), IOP measurement principles and historical measurement techniques and progress in IOP measurement devices. The authors explore the issues surrounding current thinking in IOP measurement and its...
A novel parameter for angle closure
This is a population cross-sectional study of 464 eyes that underwent swept-source optical coherence tomography (SSOCT) imaging in the dark. Eight out of 128 cross-sectional images were selected for analysis. Matlab was used to measure the iridolenticular contact area (ILCA),...
Variability between handheld fundus cameras
Handheld fundus cameras offer the potential of enhancing opportunities for telemedicine diagnosis of glaucoma, especially in underserved settings, as they are less bulky, inexpensive and don’t require skilled personnel compared to traditional table-mounted retinal cameras. This study aimed to compare...
IOP reduction and progression of high myopic glaucoma
This retrospective study of 131 eyes with high myopia (refraction >-6.0 dioptres or axial length >26mm), best corrected vision 20/40 or better, open angle and follow-up period of more than five years, were included from Korea. Based on the intraocular...
Can diuretics increase the risk of acute angle closure glaucoma?
Diuretics, used widely in the treatment of hypertension, oedema, heart failure and liver failure, have been implicated in case reports in scientific literature to be linked to bilateral acute angle closure glaucoma (AACG). The aim of this study was to...
Atopic dermatitis: Risk of glaucoma progression?
This population-based retrospective cohort study from December 5, 2003 to December 3, 2018 examined 528,469 patients with glaucoma with a diagnosis of atopic dermatitis (AD) based on diagnostic claim codes from the TriNetX Research Network, which contains real-time information on...
Oral Ibuprofen reduces early bleb failure in high risk trabeculectomy
In this retrospective cohort study, 288 eyes of 273 patients (mean ±SD age: 68.56 ±10.47 y; 32.60% females) with primary glaucoma who underwent trabeculectomy / phacotrabeculectomy at the Singapore National Eye Centre between April 2020 and April 2021 with a...
Comparison of structural and functional features in primary angle closure and open-angle glaucoma
In this large cross-sectional study, differences in structural and functional damage were assessed among patients with primary open-angle glaucoma (POAG) and primary angle closure glaucoma (PACG) with optical coherence tomography and reliable visual field testing. Two-hundred and eighty-three patients with...
