You searched for "tumour"
MicroRNA mediate retinoblastoma signal transduction
1 October 2014
| Graham Wallace
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EYE - Vitreo-Retinal
MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...
An unusual case of sellar chondroma
1 June 2014
| Claire Howard
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EYE - Neuro-ophthalmology
A single case of chondrogenic neoplasm arising from the base of the skull is presented and discussed. These benign and slow growing tumours in the sellar region are extremely rare and as such this article provides a useful insight and...
Resveratrol protects against steroid induced intraocular pressure
1 April 2016
| Graham Wallace
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EYE - General
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Glaucoma, Intraocular pressure, Resveratrol, Retina, Steroid-induced, Trabecular meshwork
Topical and systemic steroid delivery is a very effective treatment for many ocular conditions but is compromised by raised intraocular pressure which in turn leads to death of retinal ganglion cells and irreversible blindness. This is an important consideration with...
Quiz Feb/Mar 2020
5 February 2020
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EYE - General
History A 92-year-old female patient was referred for a three-month history of a left conjunctival growth with ocular irritation. Her past medical history included: hypertension, back pain and osteoarthritis, all of which were controlled by medication. On examination: vision in...
Pituitary tumours: why are they so often missed?
1 April 2017
| James F (Barry) Cullen
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EYE - Neuro-ophthalmology
Part 1: Introduction, historical background and Edinburgh connections (see also Part 2 and Part 3) Is there any ophthalmologist who has not missed a pituitary tumour? Hopefully this article will help those currently in practice to avoid such an embarrassment,...
Management of diffuse OSSN with topical chemotherapy
Ocular surface squamous neoplasia (OSSN) can be localised to the conjunctiva or, less commonly, diffusely spread over the conjunctiva and cornea. Localised OSSN can be treated by surgical removal with adjuvant cryotherapy and chemotherapy with low rates of recurrence. Diffuse...Papilloedema: an update
1 June 2016
| James F (Barry) Cullen
|
EYE - Neuro-ophthalmology
Some readers may have seen a recent report in the national newspapers of the case of a teenage girl with persistent severe headache associated with a fatal brain tumour having been undiagnosed despite many consultations with her medical advisers. It...
Neurofibromatosis type 2 – diagnosis, features and MDT approach
1 December 2021
| Jincy Kurian
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EYE - Orbit, EYE - Vitreo-Retinal, EYE - Cataract, EYE - Refractive, EYE - General
NF2 is a genetic condition caused by mutation in a single gene (NF2 gene) on chromosome 22. The NF2 gene provides instructions to produce a protein called merlin, also known as schwannomin. This protein functions as a tumour suppressor, preventing...
Developments in Ophthalmology: Ophthalmic Radiation Therapy Techniques and Applications
1 February 2015
| Sofia Rokerya
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EYE - Paediatrics, EYE - Strabismus, EYE - General, EYE - Neuro-ophthalmology
Radiation was discovered by Wilhelm Roentgen in 1895, and since then has been used to treat a variety of cancers. Its therapeutic properties have been widely used for ocular and periocular tumours and inflammatory disease, but the present era is...
Chronic lymphocytic leukaemia (CLL) of the lacrimal sac
The authors present a case series of three patients with known CLL, two of which presented with mass and epiphora and one case with epiphora alone. All three patients had initially being diagnosed and were treated for chronic dacryocystitis. Histopathological...Lacrimal gland carcinoma outcomes
1 April 2019
| James Hsuan
|
EYE - Oculoplastic
This is retrospective review of outcomes of lacrimal gland epithelial tumours treated between 1972 and 2014 at Moorfields Eye Hospital. Seventy-nine patients were reported, comprising 53 adenoid cystic carcinomas, 15 primary adenocarcinomas and 11 carcinomas ex-pleomorphic adenoma. The authors compare...