Search

Akimba mice, a model of human diabetic retinopathy

Diabetic retinopathy (DR) is a major complication of diabetes and a growing problem as the systemic disease becomes more prevalent. DR develops insidiously from an asymptomatic form through to vascular damage that leads to oedema and breakdown of the blood-retinal...

Reduced blood flow and age-related macular degeneration

This was a prospective cross-sectional study assessing changes in blood flow velocity in patients with age-related macular degeneration (AMD) using a retinal function imager. Sixty eyes with wet AMD were compared to 53 control eyes and the average blood flow...

Topical doxycycline for corneal neovascularisation

Six eyes with corneal vascularisation were treated with 1% topical doxycycline, four times a day for three weeks. The patients were reviewed at various intervals over a period of one year. The eyes selected had neovascularisation secondary to a variety...

Rotational stability of angle supported phakic IOL

The authors evaluate 50 eyes of 28 patients that underwent an angle fixated phakic intraocular lens (IOL) implantation (Acrysof Cachet). All eyes had moderate to high myopia (-5.25 to-19.63 dioptres) and IOL sizing was performed as per the manufacturer’s recommendation....

Environmental variations in endophthalmitis

In this retrospective cohort study, the authors looked at seasonal and environmental variations in 171 endophthalmitis cases out of 423,297 intravitreal injections. The incidence of this complication was not correlated to monthly snowfall, rainfall, or average temperature. There was no...

ANGPTL-4 inhibition reduces inflammation in diabetic retinopathy

Diabetic retinopathy (DR) is the most common cause of blindness in working-age humans, and numbers are rising due to increased cases of type 2 diabetes (T2D). T2D is associated with increased obesity and dyslipidaemia, which is a major risk factor...

Somatostatin protects retinal pericytes

Diabetic retinopathy (DR) is a complication of diabetes, caused by high blood sugar levels damaging the retinal microvasculature. Mechanisms, such as oxidative stress and deposition of advanced glycation end products, leads to glial cell activation and neuronal apoptosis. Pericytes, contractile...

Impact on the corneal and anterior chamber characteristics after femtosecond laser cataract surgery

Femtosecond laser cataract surgery (FLACS) is being increasingly used in the preparation for cataract surgery. Benefits of circular capsulorrhexis and reduced phacoemulsification energy have been shown in the literature. This study was designed to assess the anterior chamber characteristics and...

Refractive surgery for anisometropic amblyopia

The authors report the outcomes of refractive surgery with phakic intraocular lens (PIOL) implant for management of anisometropic amblyopia in children intolerant to conventional therapy. This was a retrospective study of 71 eyes of 71 patients of which 58 were...

Is an increased homocysteine level associated with greater risk of AMD?

Basic research studies have implicated homocysteine in causing vascular endothelial dysfunction and inflammation, and this has been borne out in large observational studies which suggested that elevated homocysteine is associated with increased risk of cardiovascular disease. In order to determine...

Clinical predictors of proliferative sickle cell retinopathy

Sickle Cell Disease (SCD) is an inherited disorder resulting in production of Haemoglobin S (HbS), which aggregates in conditions of hypoxia, acidosis or hyperosmolarity. This leads to vascular stasis, thrombosis and ischaemia. The authors present a cross-sectional study (45 consecutive...