This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.  Read our Cookies Policy.
Close
Eye News
  • Features
    • Close
    • Features
    • Allied Professions
    • Humanitarian
    • Interviews
    • AI & Oculomics
    • Ophthalmology
    • Optometry
    • Podcast videos
    • Supplements
  • Education
    • Close
    • Education
    • Learning Curve
    • Quiz
    • Top Tips
    • Trainees
    • Medico-Legal
    • The Truth Behind The Headlines
    • Case Reports
    • Pete's Bogus Journey
  • Reviews
    • Close
    • Reviews
    • Book Reviews
    • Journal Reviews
    • What's trending?
    • Tech Reviews
    • My Top Five
    • The Culture Section
  • Events
  • News
  • Product Guide
  • Industry News
  • Contact us
    • Close
    • Contact us
    • Write for Eye News
  • Home
  • Reviews
  • Journal Reviews
  • Akimba mice, a model of human diabetic retinopathy

Akimba mice, a model of human diabetic retinopathy
Reviewed by Graham Wallace

1 October 2014 | Graham Wallace | EYE - Vitreo-Retinal

Diabetic retinopathy (DR) is a major complication of diabetes and a growing problem as the systemic disease becomes more prevalent. DR develops insidiously from an asymptomatic form through to vascular damage that leads to oedema and breakdown of the blood-retinal barrier (BRB). The Akimba mouse is a cross between the Ins2Akita the Akita diabetes model and the trVEGF029 (Kimba) mouse in which photoreceptors transiently express VEGF. The resultant Akimba has a retinal microenvironment similar to advanced DR in humans. Fluoroscein leakage showing BRB damage was seen in the Kimba and Akimba mice but not Akita or wild-type mice. BRB damage was associated with angiogenesis. Moreover, mRNA for plasmalemma vesicle associated protein (PVLAP) a molecule only found in damaged BRB, was raised in Kimba and Akimba mice. However, pericyte drop-out, and decreased endothelial junction protein expression was seen only in Akimba mice These data suggest that the recently-developed Akimba mice which combines hyperglycaemia and high intraocular VEGF expression may be a good model for human DR.

Molecular analysis of blood-retinal barrier loss in the Akimba mouse, a model of advanced diabetic retinopathy.
Wisniewska-Kruk J, Klaassen I, Vogels IM, et al.
EXPERIMENTAL EYE RESEARCH
2014;122(5)123-31.
Share This
CONTRIBUTOR
Graham Wallace

Birmingham and Midland Eye Centre, Birmingham, UK.

View Full Profile
Specialty
  • EYE - Cataract
  • EYE - Cornea
  • EYE - General
  • EYE - Glaucoma
  • EYE - Neuro-ophthalmology
  • EYE - Oculoplastic
  • EYE - Oncology
  • EYE - Orbit
  • EYE - Paediatrics
  • EYE - Pathology
  • EYE - Refractive
  • EYE - Strabismus
  • EYE - Vitreo-Retinal
Archive
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013

Top Of Page

9 Gayfield Square, 
Edinburgh EH1 3NT, UK.

Call: +44 (0)131 557 4184
www.pinpoint-scotland.com

WEBSITE DETAILS
  • Cookie Policy
  • Data Protection Notice
  • Privacy Policy
  • Terms and Conditions
ABOUT US
  • Who we are
  • Register
  • Contact us
  • Contributors
  • Company Awards
DIGITAL ISSUES/GUIDELINES
  • Digital issues - Library
  • Supplements - Library
  • Guidelines
Accreditations
IPSO_FLAG_TEAL 2025.png cpdcertified.png

Pinpoint Scotland Ltd (Registered in Scotland No. SC068684) | © 2025 - Website by Gecko Agency