You searched for "melanocytes"
Practice patterns of uveal melanoma management with Iodine-125 brachytherapy
With the 2006 Collaborative Ocular Melanoma Study Group (COMS) study demonstrating no difference in survival outcomes for participants randomised to either iodine-125 brachytherapy or enucleation, the majority of primary uveal melanomas in the United States are now treated with brachytherapy....An update on inherited retinal disorders (part 1) – overview and assessment of inherited retinal disease
Part 2 of this topic can be found here Inherited Retinal Disease (IRD) is the leading cause of blindness certification in the working age population (age 16-64 years) in England and Wales and the second most common in childhood [1]....
PD-1 and retinal ganglion cell death
Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...
Differential inhibition of EAU by CTLA4 and IL-6
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...
CMV assessment
This is a retrospective, cross-sectional review of medical records from a consecutive series of patients with AIDS-related cytomegalovirus (CMV) retinitis who were examined at five HIV disease clinics in Yangon, Myanmar, in November 2006. All patients with CD4+ T lymphocytes...Pathophysiology of diabetic macular oedema: why combination therapy may be better
The prevalence of diabetes has continued to increase over the years. It is currently estimated that there are 382 million with diabetes worldwide in 2013, and that this figure is expected to rise to 592 million by 2035 [1]. In...Apr/May 2014 Quiz 1
History A 45-year-old man presents with left-sided epiphora. During a dacrocystorhinostomy (DCR), the wall of the lacrimal sac was noted to be bulky. The sac wall is biopsied and sent for routine histopathology examination. The pathologist notes a distinctive feature...Caring for adults with an ocular tumour
Detection If you screen for an intraocular tumour, dilate the pupil. If the patient is driving, use phenylephrine only. If the patient declines, document this in the casenotes. Don’t forget to look for sentinel vessels, which would indicate a ciliary...Aug/Sep 2019 Quiz
History A 73-year-old female patient was referred for rapid growth of two new lesions on the face. She had past medical history of systemic lymphoma. On examination, there was a palpable mass over the left superior orbital region and the...
Management and outcomes of congenital fibrovascular pupillary membranes (CFPM)
Congenital fibrovascular pupillary membranes (CFPM) is defined as a white fibrous membrane across the pupil which may be an ectopic iris tissue arising from the aberrant migration of neural crest cells or a variant of persistent fetal vasculature. The authors...
