Review of non-arteritic anterior ischaemic optic neuropathy
1 October 2016
| Chrysostomos D Dimitriou
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EYE - Neuro-ophthalmology
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Neuroprotection, optic nerve ischemia, optic nerve vasculature, primate models, rodent models
This article reviews the risk factors, clinical presentation and therapies that have been investigated for non-arteritic anterior ischaemic optic neuropathy (NAAION). Additionally, it provides an update from recent rodent and primate models, offering a new insight into the pathophysiology of...
Leber’s hereditary optic neuropathy: from lab to clinic
1 October 2016
| Chrysostomos D Dimitriou
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EYE - Neuro-ophthalmology
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Hereditary optic neuropathy, Leber hereditary optic neuropathy, mitochondrial optic neuropathy, optic neuropathy
Leber’s hereditary optic neuropathy (LHON) was the first clinically described mitochondrial disorder (1871). This article reviews the pathophysiology and clinical features of LHON with a focus on translational research. G11778A is currently the most common mutation worldwide and is associated...
PlusoptiX and SPOT screening
The goal of this study was to determine whether an instrument that uses referral criteria having a high specificity (plusoptiX S08) would fail to refer children who have significant amblyopia and who would have been detected by an instrument using...
Carbonic anhydrase II autoantibody specificity in retinopathy
Autoimmune retinopathy (AR) can be divided into three different categories, paraneoplastic retinopathy, including recoverin-associated retinopathy and melanoma-associated retinopathy, non-paraneoplastic autoimmune retinopathy, combined paraneoplastic optic neuropathy and retinopathy (CAR). These conditions are characterised by circulating anti-retinal autoantibodies, possibly due to a...
Enucleation refusal for retinoblastoma
1 October 2016
| Huw Edward Oliphant
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Enucleation refusal, global survival disparity, health inequalities, retinoblastoma, treatment compliance, treatment delay
Retinoblastoma is the most common eye cancer in childhood, with enucleation rarely being the only lifesaving surgical option, especially where evidence of extraocular spread is apparent. This study sought to survey a global pool of eye care professionals with regards...
Dog bite lid lacerations
The characteristics of dog bite induced lid trauma are described in a large cohort of paediatric patients and the success rate of early repair of lacerations involving the lacrimal system. This is a retrospective review of 438 patients: 73 with...
Long-term esotropia and exotropia alignment
The authors review surgical outcomes for 317 children having surgery for esotropia (n=235) or exotropia (n=82) for comparative analysis using survival curves. Esotropia surgery was undertaken at a mean of 42 months; exotropia surgery at a mean of 60 months...
Stimulus type vs. convergence measures
The aim of this study was to investigate if near point of convergence (NPC) would improve when a fixation target with centrally placed 3-D features (to increase binocular disparity stimulus) was used in comparison to a target using only centrally...
Propranolol treatment of infantile haemangioma
This is a retrospective review of 104 patients treated for infantile haemangioma between January 2009 and July 2012. All patients underwent pretesting either with protocol A (administration of test dose with routine observations) or protocol B (cardiology clinic assessment, including...
Rituximab efficacy for juvenile idiopathic arthritis
This is a retrospective study about the long-term efficacy of rituximab in patients with severe juvenile idiopathic arthritis (JIA)-associated uveitis. A total of eight patients (15 eyes) were recruited in this study in a single tertiary referral centre from Italy....
Incidence, characteristics and risk factors for ROP
This is a retrospective study performed at Seoul St Mary’s Hospital between the period of January 2009 to December 2013. The study was to determine the incidence and clinical features of, and risk factors for, retinopathy of prematurity (ROP) in...
Combined ranibizumab and ablative therapy for Coat’s disease
1 October 2016
| Bheemanagouda Patil
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EYE - Vitreo-Retinal
The aim of this study was to observe the efficacy of intravitreal ranibizumab (IVR) combined with laser photocoagulation or cryotherapy, for Coats’ disease. Patients younger than 16 years of age who were diagnosed with Coats’ disease were included in this...
