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Nicotine accelerates diabetes induced retinal changes
This study investigated the influence of nicotine in an experimentally induced diabetic rat model. They used non-invasive high-resolution spectral domain optical coherence tomography (SD-OCT) imaging to provide quantitative information on the temporal alterations of retinal structures at the micrometer resolution...
ANGPTL-4 inhibition reduces inflammation in diabetic retinopathy
Diabetic retinopathy (DR) is the most common cause of blindness in working-age humans, and numbers are rising due to increased cases of type 2 diabetes (T2D). T2D is associated with increased obesity and dyslipidaemia, which is a major risk factor...
Akimba mice, a model of human diabetic retinopathy
Diabetic retinopathy (DR) is a major complication of diabetes and a growing problem as the systemic disease becomes more prevalent. DR develops insidiously from an asymptomatic form through to vascular damage that leads to oedema and breakdown of the blood-retinal...Choroidal folds
Choroidal folds are undulations of the choroid, Bruch’s membrane and pigment epithelium, with wrinkling of the overlying retina. They may be idiopathic but can also be caused by a number of different conditions. Case report A 60-year-old male patient was...Feb/Mar 2014 Quiz 1
History A 55-year-old diabetic male presents with some annoying floaters in his left eye. Slit-lamp examination shows multiple well defined bodies within the vitreous cavity, in an eye otherwise showing background diabetic retinopathy. The patient elects to undergo a vitrectomy....Pathophysiology of diabetic macular oedema: why combination therapy may be better
The prevalence of diabetes has continued to increase over the years. It is currently estimated that there are 382 million with diabetes worldwide in 2013, and that this figure is expected to rise to 592 million by 2035 [1]. In...
One-year result of XEN45 implant for glaucoma: efficacy, safety, and postoperative management
The authors report a retrospective, non-randomised interventional case series of 39 patients who underwent a standalone XEN45 implantation. All 39 patients (female: male=1.2: 1) completed 12-month follow-up. Mean age was 70.1 years (range 32–92). Primary outcome measures were the intraocular...
