The purpose of this study was to quantify and evaluate the effect of rigid gas permeable contact lenses (CLs) on visual acuity, contrast sensitivity and motor parameters of involuntary eye movements in hyperopic patients with infantile nystagmus syndrome (INS). This was a prospective study of 16 patients (eight female and eight male) with a mean age of 18.6 years ±4.9. Mean spherical equivalent refractive error was +1.50±2.35D. Monocular and binocular visual acuity showed significant improvement after use of CLs. Mean monocular visual acuity of 20/72 improved to 20/66 whilst binocular best corrected visual acuity improved from a mean of 20/60 to 20/60. A significant increase in contrast sensitivity at low and median frequencies was found but not at high frequency. Nystagmus frequency, amplitude and intensity improved significantly. The authors conclude that use of CLs in hyperopic patients with INS can improve visual acuity, contrast sensitivity and nystagmus intensity.