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PD-1 and retinal ganglion cell death
Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...
Prevalence and incidence of uveitis
Uveitis encompasses a group of diseases characterised by the inflammation of fovea uvea which are potentially vision threatening. However, the frequency of this condition is unclear. This systematic review and meta-analysis aimed to provide estimates of the frequency of uveitis...
Occult central retinal artery occlusion
Central retinal artery occlusion (CRAO) is a sight-threatening condition resulting from occlusion of the central retinal artery and hypoperfusion of the inner retina. Early on, fundal examination may be normal. The authors present a retrospective case series of 11 patients...
Practice patterns in managing exogenous endophthalmitis
The authors of this study conducted a global survey of medical institutions regarding management of exogenous endophthalmitis to assess current practice patterns for this sight-threatening emergency. Thirty-six (of 42 institutions) responded and were included in the analysis. Results were as...
Scleral perforation after strabismus surgery
The aim of this study was to report the incidence, risk factors, treatment and outcomes of scleral perforation as a vision-threatening complication of strabismus surgery. The review included 12 papers: four prospective, two retrospective, two surveys, one review, two animal...
Differentiating orbital cellulitis from non-specific orbital inflammation
This is a retrospective study looking at whether common laboratory investigations can help differentiate between orbital cellulitis (OC) and non-specific orbital inflammation (NSOI). NSOI is a diagnosis of exclusion following negative investigations for systemic diseases such as IgG4-related disease, granulomatosis...
Diagnostic yield of routine metastatic work-up in conjunctival melanoma
Conjunctival melanoma (CM) is a rare but potentially aggressive malignancy of the ocular surface with high rates of local recurrence and metastasis. Eighty-one consecutive patients with invasive conjunctival melanoma treated by the senior author over the course of 23 years...Moorfields to start new retinal detachment clinical trial
Moorfields to start new retinal detachment clinical trial following £1.2 million MRC DPFS grant awarded to UCL and Moorfields Eye Hospital.An Inconvenient Truth: Pete’s hidden curriculum Part 4
“What gets us into trouble is not what we don’t know. It’s what we know for sure that just ain’t so.” The above is a quote attributed to Mark Twain from the 2006 documentary, An Inconvenient Truth, which follows Al...
Video Atlas of Ophthalmic Suturing Fundamentals and Techniques
Good suturing technique is a fundamental requirement of all surgeons. With the advent of modern minimal suturing and sutureless techniques, junior doctors have less exposure and hence less experience with suturing skills. Good microsurgical suturing skills can only be mastered...
Treatment of Sjogren’s Syndrome dry eye in mouse model
Sjogren’s syndrome (SS) is a chronic autoimmune disease characterised by inflammation of the exocrine glands, specifically the salivary and lacrimal glands that produce saliva and tears, respectively. The immune-mediated attack on the salivary and lacrimal glands leads to the development...
