Retinal changes in Leber hereditary optic neuropathy

The objective of this study was to describe the changes in the retinal ganglion cell complex (GCC) relative to the retinal nerve fibre layer (RNFL) over time, in patients with Leber’s hereditary optic neuropathy (LHON). For this study, 21 patients...

Hereditary profile of retinal detachment

This review sought to clarify some of the heritable elements of rhegmatogenous retinal detachment (RRD). The familial element of RRD is well established, with the sibling recurrence risk ratio being 2.1 (Mitry and colleagues), and the parent-offspring recurrence risk ratio...

Automated Bruckner device accuracy

The authors developed a Bruckner device, examined volunteers and determined the relation between the luminance of the red fundus reflex and eye rotation. Eye rotation was varied continuously both horizontally (-7 to 8 degrees) and vertically (five degree total range)...

PD-1 and retinal ganglion cell death

Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...

ARN in North Africa

Acute retinal necrosis (ARN) is a rare cause of uveitis. This paper aims to outline the clinical features of 12 patients with ARN in a referral centre in Tunisia, North Africa. A retrospective review of case notes was carried out....

A case series of acute visual loss following excessive alcohol and / or drug use

This study presents three cases of so called Saturday night retinopathy, an acute visual loss following intravenous drug abuse and stupor, leading to continuous pressure on the orbit while asleep. All three cases presented with acute vision loss and had...

Air toxicity on retinal pigment epithelium

This study investigated the potential toxic effects of air on primary human retinal pigment epithelial (RPE) cells in vitro. Clinically during pars plana vitrectomy air is used as either a temporary tamponade during air-fluid exchange or mixed with gas to...

Structural effects of migraine on the retina

Migraine is a common, chronic, multifactorial neuro-vascular disorder typically characterised by recurrent attacks of disabling headache and autonomic nervous system dysfunction (migraine without aura). Up to one third of patients also have neurological aura symptoms (migraine with aura). The objective...

Nicotine accelerates diabetes induced retinal changes

This study investigated the influence of nicotine in an experimentally induced diabetic rat model. They used non-invasive high-resolution spectral domain optical coherence tomography (SD-OCT) imaging to provide quantitative information on the temporal alterations of retinal structures at the micrometer resolution...

Are retinal vein occlusions seasonal? And if so why might that be?

Some studies have reported a strong seasonal pattern to central retinal vein occlusion (CRVO) occurrence with a peak in January, but other studies have failed to replicate this finding. The authors sought to determine data for Stockholm’s seasonal variation in...

Retinal blood flow changes in glaucoma

This study examined the changes in retinal blood flow and vessel diameter after IOP reduction in high- and low-pressure glaucoma; exfoliation glaucoma (ExG) and normal-tension glaucoma (NTG). Glaucoma progression is seen at times in eyes despite IOP reduction and changes...

A rare case of post-traumatic central retinal artery occlusion

Central retinal artery occlusion is rarely associated with traumatic optic neuropathy, this case report details of one such case. The reported case is of a ten-year-old boy presenting after a fall from height with loss of vision in one eye....