Case report review of children with septo-optic dysplasia and optic nerve hypoplasia
3 April 2023
| Claire Howard
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EYE - Neuro-ophthalmology
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Vision, nystagmus, optic nerve hypoplasia, paediatrics, septo-optic dysplasia, strabismus
Septo-optic dysplasia (SOD) and optic nerve hypoplasia (ONH) cause congenital visual impairment. Their aetiology is mostly unknown. The authors aim was to investigate the prevalence of specified ophthalmological features in patients with these disorders. These features included impaired visual acuity,...
Investigating MOG-IgG as a cause for optic perineuritis
5 August 2020
| Claire Howard
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EYE - Neuro-ophthalmology
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Optic perineuritis, myelin oligodendrocyte glycoprotein (MOG), aquaporin-4 (AQP4), optic neuritis, optic nerve sheath
Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but in most cases is considered idiopathic. Diagnosis is established by magnetic resonance imaging (MRI) with the demonstration of optic nerve sheath enhancement with sparing of the optic...
Examination of optic disc drusen using computer-based fundus analysis
5 August 2020
| Claire Howard
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EYE - Neuro-ophthalmology
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Optic disc drusen, optic nerve head drusen, optic nerve head microvasculature, optic nerve head angioarchitecture
This case-control study analysed the optic disc angioarchitecture in optic disc drusen (ODD) using computer-based fundus examination. A group of ODD patients were compared to a group of healthy controls with normal optic discs. The cohort included 30 healthy volunteers...
Glaucoma and capillary perfusion
1 August 2019
| Kurt Spiteri Cornish
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EYE - Glaucoma
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Glaucoma, OCTA, field of vision, intraocular pressure, macula, optic nerve
Elevated IOP is important but not the sole factor responsible for retinal ganglion cell (RGC) death and optic nerve damage in glaucoma. There is increasing evidence that visual loss correlates with macular inner retinal thinning. A total of 148 eyes...
Differences in elastometry of cornea and optic nerve head in both eyes of patients with NAION
1 February 2019
| Claire Howard
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EYE - Neuro-ophthalmology
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Corneal hysteresis, corneal resistance factor, non-arteritic anterior ischaemic neuropathy, optic nerve head biomechanics, real-time elastography
Non-arteritic anterior ischaemic optic neuropathy (NAION) is an important cause of visual loss in the middle aged and elderly population. This prospective cross-sectional study investigates the biomechanical properties of optic nerve head (ONH) and cornea in both eyes of patients...
Use of the RAPDx device to evaluate efficacy of treatment in patients with optic nerve disease
1 October 2018
| Claire Howard
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EYE - Neuro-ophthalmology
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Detection rate, optic nerve disease, relative afferent pupillary defect, standard values
The RAPDx objectively determines the RAPD magnitude by alternately presenting light stimuli to each eye and deriving amplitude and latency scores. The authors of this paper evaluated the amplitude and latency scores from the RAPDx together with other ophthalmic investigations...
Histopathological changes in rabbit retinitis pigmentosa
1 April 2017
| Claire Howard
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EYE - Neuro-ophthalmology
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Optic disc, optic nerve, rabbit, retinal ganglion cell, retinitis pigmentosa
The authors report the histopathological changes of retinal ganglion cells (RGCs), optic disc and optic nerve in rabbit with advanced retinitis pigmentosa (RP). RP was recreated in rabbits by using bacterial artificial chromosome transgenesis, with the purpose of increasing understanding...
Review of non-arteritic anterior ischaemic optic neuropathy
1 October 2016
| Chrysostomos D Dimitriou
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EYE - Neuro-ophthalmology
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Neuroprotection, optic nerve ischemia, optic nerve vasculature, primate models, rodent models
This article reviews the risk factors, clinical presentation and therapies that have been investigated for non-arteritic anterior ischaemic optic neuropathy (NAAION). Additionally, it provides an update from recent rodent and primate models, offering a new insight into the pathophysiology of...
Use of RAPDx device with optic nerve disease
1 August 2016
| Claire Howard
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EYE - Neuro-ophthalmology
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Detection rate, optic nerve disease, relative afferent pupillary defect, standard values
The authors have previously reported on use of the RAPDx device for evaluating relative afferent pupillary defects (RAPD). RAPDx objectively determines the magnitude of RAPD by presenting light stimuli alternately to pairs of eyes with laterality. The parameters of amplitude...
Functional visual field loss using automated static perimetry
1 February 2015
| Nana Theodorou
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EYE - Neuro-ophthalmology
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functional visual field loss, optic nerve, perimetry, visual fields
Functional visual field loss is traditionally assessed by kinetic perimetry, typically producing spiralling isopters. This study looked at the spatial distributions of functional field deficits using automated static perimetry. A retrospective review of automated perimetry records was conducted using a...
