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  • Investigating MOG-IgG as a cause for optic perineuritis

Investigating MOG-IgG as a cause for optic perineuritis
Reviewed by Claire Howard

5 August 2020 | Claire Howard | EYE - Neuro-ophthalmology | Optic perineuritis, myelin oligodendrocyte glycoprotein (MOG), aquaporin-4 (AQP4), optic neuritis, optic nerve sheath
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Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but in most cases is considered idiopathic. Diagnosis is established by magnetic resonance imaging (MRI) with the demonstration of optic nerve sheath enhancement with sparing of the optic nerve itself. Myelin oligodendrocyte glycoprotein (MOG)-IgG-positive optic neuritis has been reported in association with optic nerve sheath enhancement. The authors present two MOG-IgG patients with clinical, radiological and therapeutic response consistent with optic perineuritis. They suggest that MOG-IgG may therefore account for other cases of previously described idiopathic optic perineuritis. In summary, patients presenting with vision loss with optic nerve sheath enhancement on MRI should prompt testing for MOG-IgG. A confirmed diagnosis can assist in decision-making regarding treatment and prognosis.

Myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-positive optic perineuritis.
Lopez-Chiriboga AS, Van Stavern G, Flanagan EP, et al.
NEURO-OPHTHALMOLOGY
2020;44(1):1-4.
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CONTRIBUTOR
Claire Howard

Salford Royal NHS Foundation Trust, Salford, UK.

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