You searched for "disease"

1762 results found

Visual acuity outcomes in Coat’s disease by classification stage

This is a retrospective study of 160 consecutive patients with Coat’s disease under the Shields classification, with Snellen visual acuity (VA) pre and post treatment. Affected eyes were categorised based on the Shields classification: Stage 1: retinal telangiectasia onlyStage 2a:...

Using contrast acuity and rapid number naming in Huntington’s disease

This study aimed to evaluate afferent and efferent visual function in Huntington’s disease (HD). HD is often portrayed by abnormal saccadic eye movements and afferent visual pathway involvement however these are poorly characterised and difficult to quantify at the bedside....

Test combination which could detect prodromal Alzheimer disease

The authors prospectively recruited a convenience sample of individuals aged over 65 and either with a diagnosis of mild cognitive impairment (MCI) due to Alzheimer disease or normal cognition. Other types of dementia and severe neurological conditions were excluded. All...

Benefit of selenium and vitamin D supplementation in thyroid eye disease

There is some limited evidence of as association between thyroid eye disease (TED) and nutritional deficiencies including selenium and vitamin D. Prior studies show that selenium can reduce TPO-antibody concentrations and improve hypothyroidism and post-partum thyroiditis. Limited evidence also shows...

Saccadic eye movements in young-onset Parkinson’s disease

The objective of this study was to understand control of saccadic eye movements in patients with young onset Parkinson’s disease (YOPD) where onset of disease symptoms appears early in life (<40 years of age). Functional magnetic resonance imaging (fMRI) was...

Outcomes of combined medial and laser treatment for advanced Coat’s disease

In this study, the anatomical and visual outcomes of paediatric patients with advanced stage 3+ Coat’s disease are reported. Patients were treated with a combination of intravitreal ranibizumab, laser photocoagulation and methyl prednisolone acetate. This was a retrospective review of...

Treatment of severe chronic ocular graft-versus-host disease

A retrospective study from Cologne, Germany, between November 2012 to March 2015, of 17 patients with graft-versus-host disease (GVHD) treated with 100% single use vials autologous serum eye drops in sealed system. Visual acuity, corneal staining, frequency of artificial tears,...

Can 3D facial imaging improve patient management in disfiguring eye disease?

Fight for Sight is the leading UK charity funder of eye research. Since the 2013 Sight Loss and Vision Priority Setting Partnership we have encouraged our researchers to work on priorities jointly identified by people affected by sight loss and...

Sustainability in eyecare: Are virtual clinics the way forward in the diagnosis and monitoring of retinal disease?

Virtual clinics can be used successfully in screening and management of ocular conditions such as diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration. Virtual clinics should be a considered as a more clinically appropriate modality of consultation, diagnosis and...

Renewed momentum in ocular gene and cell therapy, broadening application to chronic disease

Gene and cell therapies offer the prospect of ground-breaking new avenues for the treatment of diseases, reflected in a renewed explosion of interest and investment in retinal gene therapy. Rod McNeil reports recent clinical trial readouts across a diverse range...

A review of neuro and retinal imaging findings in Alzheimer’s disease

The authors present a systematic review with the aim of assessing the relationship between retinal and cerebral changes in Alzheimer’s disease (AD), mild cognitive impairment and pre-clinical AD. A total of 23 articles met the inclusion criteria of the review,...

Ovarian hormones drive onset of Sjogren’s disease in mice

Sjogren’s syndrome (SS) is a debilitating, sight-threatening, systemic autoimmune disease with no effective treatment available. SS is characterised by lacrimal gland lymphocytic infiltration and epithelial cell death, as well as by the presence of serum autoantibodies. Patients have severe dry...