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There is some limited evidence of as association between thyroid eye disease (TED) and nutritional deficiencies including selenium and vitamin D. Prior studies show that selenium can reduce TPO-antibody concentrations and improve hypothyroidism and post-partum thyroiditis. Limited evidence also shows that vitamin D supplementation may be a potential adjunct treatment strategy to slow disease progression due to its role in innate and adaptive immunity. The authors report results of a retrospective chart review on all patients seen between 2016 and 2017 at their Houston Clinic, with a diagnosis of TED. Thirty-five patients met inclusion criteria and had serum 25-hydroxyvitamin D levels available, and 19 had selenium levels available. On analysis, 7/35 (20%) had vitamin D deficiency, and 11 (31%) had vitamin D insufficiency. No patients had selenium deficiency. In conclusion, although both selenium and vitamin D supplements have been recommended for TED, further investigation is necessary to justify benefits for patients with TED. Further studies should include a larger sample size and have a prospective methodology.

Vitamin D and selenium in a thyroid eye disease population in Texas.
Sadaka A, Nguyen K, Malik A, et al.
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Claire Howard

Salford Royal NHS Foundation Trust, Salford, UK.

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