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Understanding the extracellular matrix in uveal melanoma
This review examines how the extracellular matrix (ECM) is remodelled throughout uveal melanoma development, from the eye to the liver. Uveal melanoma, the most common primary intraocular malignancy in adults, carries a poor prognosis due to its propensity for hepatic...
Role of amniotic membrane in ocular surface disease
This comprehensive review traces the use of amniotic membrane in ophthalmology from its first documented application in ocular surface reconstruction in the 1940s through the improved processing and preservation methods that drove renewed clinical interest in the late 20th century....Quiz Feb/Mar 2024
History A 21-month-old boy presented to his local ophthalmology department with a left proptotic eye from a growing cystic lesion known to be present from birth. Notes taken on presentation were: Known left microphthalmia with chorio-retinal coloboma, contralateral eye was...Global health and conflict: the unseen consequences
Global eye health inequalities stem from poor access to affordable care, causing preventative vision impairment and blindness. In 2020, a study showed that 510 million people, the majority being in low-income and middle-income countries, had uncorrected near vision impairment simply...Retinoblastoma management update (part 2): treatment, screening and surveillance, long-term follow-up and new developments
Retinoblastoma treatment requires significant multidisciplinary input, but early detection through raising awareness remains key to improving outcomes. In the second article of a two-part series, Manoj Parulekar discusses retinoblastoma management, screening and research. This article has been published in two...
Vision loss during Eylea treatment for AMD
This report investigated patients who lost more than two lines of vision despite periodic injections of aflibercept and explored the factors associated with vision loss. One hundred and ninety-six eyes were included in this study over a two year period....
Stromal cell alignment in damaged cornea
Stromal keratocytes are responsible for wound healing in the cornea following damage. Keratocytes at the site of injury become activated and differentiate to myofibroblasts which secrete extracellular matrix (ECM) to close the wound, a response mediated by transforming growth factor...
OCTA in angioid streaks
This paper reports on the optical coherence tomography angiography (OCTA) features of choroidal neovascularisation (CNV) secondary to angioid streaks and the ability to predict CNV activity. A total of 38 eyes of 19 patients were included in the study. Thirty...Retinoblastoma management update (part 1): clinical features, diagnosis and genetics
The first of a two part series, this article will discuss the clinical features, diagnosis and genetic aspects of retinoblastoma. Manoj Parulekar is based at Birmingham Children’s Hospital, one of the two designated national retinoblastoma and paediatric ocular oncology treatment...An uncommon late postoperative complication of combined cataract surgery and intravitreal triamcinolone injection
Case report A 64-year-old female with diabetic maculopathy (DMO) underwent phacoemulsification with intraocular lens (IOL) implantation in her right eye combined with intravitreal triamcinolone (IVTA). Diabetes control was poor with HbA1c (IFCC) of 119mmol/mol and blood sugar level of 27mmol/L....Aug/Sep 2019 Quiz
History A 73-year-old female patient was referred for rapid growth of two new lesions on the face. She had past medical history of systemic lymphoma. On examination, there was a palpable mass over the left superior orbital region and the...
