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Ophthalmologica journal cover image.

Effect of syringe-filling technique and risk for endophthalmitis after intravitreal injection of anti-VEGF agents

2 August 2022 | | EYE - Vitreo-Retinal | Aflibercept, Anti-vascular endothelial growth factor, Bevacizumab, Endophthalmitis, Filling, Prefilled syringe, Ranibizumab, Syringe
In this retrospective study the authors compare the risk for post-injection endophthalmitis between different anti-vascular endothelial growth factor (VEGF) agents and syringe preparation technique. This multicentre study included 197,402 injections. The drugs included in this study were three Anti-VEGF agents...
Ophthalmologica journal cover image.

Post hoc analysis of the CANTREAT randomised trial

1 December 2023 | | EYE - Vitreo-Retinal | Age-related macular degeneration, Randomized clinical trial, Ranibizumab, Treat-and-extend
CANTREAT, a Canadian multicentre two-year randomised trial compares treat and extend treatment (T&E) relative to the monthly administration of Ranibizumab in nAMD. Two-hundred and eighty-five treatment-naïve patients with nAMD were randomised to receive either a once-monthly dosing or T&E regimen...
Ophthalmologica journal cover image.

Displacement of submacular haemorrhage – comparative study pneumatic displacement versus subretinal cocktail injection

3 October 2024 | | EYE - Vitreo-Retinal
The authors report a multicentre retrospective interventional case series study comparing the outcome of submacular haemorrhage (SMH) using pneumatic displacement with intravitreal expansile gas versus treatment with pars plana vitrectomy (PPV) versus subretinal injection of tissue plasminogen activator (tPA), anti-vascular...

Efficacy and safety of intravitreal faricimab in nAMD, DME and RVO

30 January 2025 | | EYE - Vitreo-Retinal
This paper is an analysis of data extracted from 13 eligible studies in the context of neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO), collected from systematic literature search of MEDLINE, Embase, and Cochrane...

AI can identify treatment gaps for patients with macular disease, study shows

10 November 2025 | artificial intelligence, AMD, new studies, treatment analysis
Using artificial intelligence (AI) in eye clinics could reduce both undertreatment and overtreatment of neovascular or ‘wet’ age-related macular degeneration (AMD). AMD is the leading cause of irreversible vision loss in older people and accounts for around 1 in 10...
Ophthalmologica journal front cover image.

Intravitreal Aflibercept (IVT-AFL): treatment of macular oedema secondary to RVO

2 December 2025 | | EYE - Vitreo-Retinal
This paper is a sub-group analysis of the real-world effectiveness, treatment patterns, and safety of IVT-AFL in patients with macular oedema secondary to retinal vein occlusion (RVO) in Italy. One hundred and fifity-two treatment-naïve and 50 pretreated patients were enrolled...

Myasthenia gravis presenting with isolated ptosis: a poorly studied subgroup

1 February 2015 | | EYE - Vitreo-Retinal
Investigation into the cause of one isolated symptom or sign can be challenging if that particular sign may be caused by a variety of pathological processes, affecting different tissues, and presenting to different specialties. Unilateral ptosis is a case in...

Another plant-based remedy for the eye?

5 June 2020 | | EYE - Cornea, EYE - Glaucoma, EYE - General
Simerdip Kaur takes a look at the latest ophthalmology-related news stories and asks which are based on facts and which are ‘fake news’. Headline: Another plant-based remedy for the eye? What do the nicknames Mary Jane, tea, and 420 all...

Is patient masking leading to an increase in post-op infection after eyelid surgery?

21 October 2020 | | EYE - Oculoplastic
Due to the COVID-19 pandemic, the use of facemasks or face coverings in the clinical setting has become necessary. It is important to recognise that facemasks can be a source of infection after eye surgery and consider ways to minimise...

AI breakthrough brings geographic atrophy treatment a step closer

20 September 2021
A team led by Dr Konstantinos Balaskas at Moorfields Eye Hospital Reading Centre has developed a fully automated, deep-learning model (algorithm) that can detect and quantify geographic atrophy using standard optical coherence tomography (OCT) scans.

Emerging therapies for geographic atrophy: complement inhibitors show potential to slow progression and preserve RPE and photoreceptor integrity

5 June 2023 |
Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD) characterised by progressive, irreversible loss of the retinal pigment epithelium (RPE) and photoreceptors and is estimated to account for approximately 10% of AMD-related blindness [1-4]. The Age-Related Eye...

Retinopathy of prematurity treatment in the South West of England: long-term outcomes 1997-2008

1 December 2014 | | EYE - Vitreo-Retinal
Retinopathy of prematurity (ROP) is a condition that affects the developing retinal vascular system of pre-term babies. If left untreated, ROP can lead to severe visual impairment. The severe visual impairment caused by untreated ROP can be prevented by screening...