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Leber’s hereditary optic neuropathy: from lab to clinic
Leber’s hereditary optic neuropathy (LHON) was the first clinically described mitochondrial disorder (1871). This article reviews the pathophysiology and clinical features of LHON with a focus on translational research. G11778A is currently the most common mutation worldwide and is associated...Principles of management
Whatever section of pathology is to blame and wherever it strikes, the aim of treatment is always the same. Find the cause if you can. Establish the effects of the cause. Halt the pathological process if you can. Reverse its...Planes, trams, and auditoriums: Beware predatory conferencing
Predatory open-access journals and predatory conferences are considered the two main areas of predatory infiltration in academic medicine that are of growing concern [1–7]. Unsolicited publishing requests from potentially predatory publishers occur frequently among faculty in ophthalmology [8]. Predatory conferencing...Cavernous sinus syndrome
Anatomically the cavernous sinus is a plexus of multiple veins that are connected and within this plexus there are several important vascular and neurological structures. These include cranial nerves III, IV, V1 (and sometimes V2), VI as well as the...Behind the eyes: Unravelling the mystery of a painless progressive proptosis
Orbital fungal infections have the potential to give rise to serious complications. While these infections typically originate in the sinuses, patients may initially exhibit ocular symptoms. As a result of the diverse and often vague clinical manifestations (especially during the...Vision on the line: Managing orbital trauma in a 30-year-old surgeon after a football injury
Blunt orbital trauma is a common consequence of sports injuries. Although retrobulbar haemorrhage is frequently associated with orbital compartment syndrome (OCS), the severity of clinical signs can outweigh imaging findings. Early recognition and intervention, such as lateral canthotomy and cantholysis...Globes in space: What would happen to our globes on the globe of Mars?
Many films have been made regarding life on alternative planets. With the Mars One mission approaching in 2023, there are high expectations regarding future interplanetary travel. The authors provide an ophthalmology perspective on what could happen to our eyes if...A paediatric case of central retinal artery occlusion following antibiotics and decompression surgery for orbital cellulitis
Orbital cellulitis is an ophthalmic emergency that warrants urgent management in the hospital setting [1]. This occurs more frequently in the paediatric population where it is often secondary to sinus infections. Delay in treatment could result in severe complications including...
OCT-A imaging in Grave’s orbitopathy and orbital decompression
In this case series of 12 patients and 24 orbits, the authors describe the changes in the optic nerve and peripapillary blood vessel density in patients with moderate to severe Grave’s Orbitopathy (GO) undergoing orbital decompression. The patients undergoing orbital...
