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Acute uveitis from late migration of soft lens matter 10 years post cataract surgery

3 June 2021 | | EYE - Cataract, EYE - Refractive, EYE - Imaging, EYE - General
A 58-year-old Caucasian male presented to the emergency eye clinic with a two-day history of a painful, red left eye and blurred vision. His past ocular history included uncomplicated left phacoemulsification cataract surgery in 2010 and left retinal detachment repair...

Placement of an eyelid weight as an upper lid spacer for lagophthalmos

1 February 2016 | | EYE - Neuro-ophthalmology
Upper lid loading with a weight is a well described procedure for the treatment of lagophthalmos and exposure keratopathy. The authors describe a modification of this procedure whereby the levator aponeurosis is recessed in combination with supratarsal weight implantation. The...

MicroRNA mediate retinoblastoma signal transduction

1 October 2014 | | EYE - Vitreo-Retinal
MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...

MicroRNA inhibits corneal neovascularisation

1 August 2018 | | EYE - Cornea, EYE - General | Biomechanical stress, Corneal epithelium, MicroRNA-204, Neovascularization, VEGF, VEGFR2
MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...

Corneal stroma modelling under hypoxic conditions

1 August 2018 | | EYE - Cornea, EYE - General | Confocal fluorescence microscopy, Cornea, Corneal organ culture, Extracellular matrix, Stroma
The cornea is exposed to hypoxia under several conditions including sleep, inflammation and wound healing. Being an avascular tissue to maintain transparency, how the cornea homeostatic controls oxygen tension is important. To address this process two models were utilised; a...

The effect of everolimus on retinal pigment epithelium and proliferative vitreo-retinopathy

1 August 2018 | | EYE - Vitreo-Retinal
The principal cells involved in proliferative vitreo-retinopathy (PVR) are retinal pigment epithelial cells (RPE). Everolimus is a drug used in renal cell carcinoma which targets and inhibits a key regulatory protein in cancer (mTOR). In this study, the authors investigated...

Enzymatic clearance of anterior chamber infiltrate in uveitis

1 February 2014 | | EYE - Vitreo-Retinal
Aqueous humour (AH) which fills the anterior chamber (AC) of the eye provides nutrients to the cornea and the lens. Clearance of cellular and particular matter from AH is necessary for good visual acuity. In part this is achieved by...

International medical graduates in ophthalmology

4 December 2023 | | EYE - General
IMGs in the NHS The General Medical Council (GMC) defines an international medical graduate (IMG) as someone who has obtained their primary medical qualification outside the European Economic Area (EEA) [1], meaning that an IMG is a medical doctor whose...

Sustainability in eyecare: Climate action in eyecare

4 August 2021 | | EYE - General
Climate change will cause disruption to critical eyecare services and increases in rates of eye disease around the world. The International Agency for Prevention of Blindness has recommended 10 key areas of action on how the eyecare sector can address...

In vivo confocal microscopy, principles and use in keratitis Part 1: Principles

1 April 2018 | | EYE - Cornea, EYE - Imaging
In 1968 Maurice introduced the concept of high powered specular microscopy, it was in that very year that the first scanning confocal microscope was proposed. Marvin Minsky developed the first confocal microscope in 1955 named the ‘double focusing scanning microscope’....

Making sense of the orthoptic assessment

1 April 2020 | | EYE - Cataract
Following the Specialty Trainee article on this topic in the February/March 2020 issue, Joe Smith provides a more detailed breakdown of the orthoptic report. Orthoptists investigate, diagnose and manage a wide variety of patients with varying problems. In this article,...

Management of proliferative diabetic retinopathy

1 August 2014 | | EYE - Vitreo-Retinal
Diabetic retinopathy is a major cause of blindness in the working-age population. Due to the worsening global epidemic of diabetes, the incidence of morbidity caused by the disease is set to increase [1]. The prevalence of diabetes in the UK...