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MicroRNA mediate retinoblastoma signal transduction
MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...
Glasses or not?
In this excellent review article, the authors discuss how some hyperopes avoid strabismus but also ask why the youngest infants escape strabismus and older patients go on to decompensate. The review considers a number of related aspects and their inter-relations...
Paediatric enucleation in a tertiary eye centre in North China, 2001-2015
The authors review the demography and aetiology of paediatric enucleation over a 15-year period. A total of 9307 paediatric ophthalmic inpatients ranging from 0 to 14 years who underwent surgery at Shandong Eye Institute over the past 15 years were...
Review of the use of amniotic membrane in restrictive strabismus
This literature review was undertaken to investigate the indications, complications and final results of amniotic membrane (AM) transplantation in ocular motility restrictions. The review (of 1103 papers) outlines the healing process plus use of AM. Excluded papers were those of...
Cataract progression after Nd-YAG laser iridotomy in primary angle-closure suspect eyes
A total of 889 of eligible bilateral primary angle-closure suspect (PACS) patients were recruited from the Zhongshan Angle Closure Prevention Trial. One randomly selected eye received laser peripheral iridotomy (LPI), while the fellow remained untreated. Cataract was graded by the...
The expanding spectrum of idiopathic intracranial hypertension
This is a review article from a tertiary centre in Atlanta, US. With rising obesity rates and increasing access for MRI scans there has been a large increase in patients requiring an urgent papilloedema check with incidental findings on MRI...NYU Langone Health performs world’s first whole-eye & partial-face transplant
Landmark whole-eye transplant is a major paradigm shift for potential vision therapies.A Nightmare on Doctor Street: Two
Just when you thought it was safe to go back into the clinic room… The quote below comes from Rudy Baylor, a graduate fresh out of law school and recruited by a ruthless ambulance chaser in the legal drama movie,...Prognostic AI for diabetic retinopathy: Towards the first prospective trial in the UK
Artificial intelligence (AI) is frequently described as having the capacity to dramatically change and improve healthcare. One extensively studied application of AI in ophthalmology involves the diagnosis of diabetic retinopathy (DR) or diabetic maculopathy (DM) using retinal imaging. An emerging...
Oral azithromycin for meibomian gland disease
Oral tetracyclines have been the traditional systemic treatment of blepharitis and acne rosacea, through inhibiting bacterial lipase production and reducing fatty acids. However, tetracyclines have a number of adverse side-effects and are required to be taken for a long duration...
Comparison of SS-OCT and SD-OCT in polypoidal choroidal vasculopathy
Swept source OCT (SS-OCT) is known to have a longer wavelength than spectral domain OCT (SD-OCT), allowing deeper penetration into retinal and choroidal layers. The aim of this study was to investigate whether SS-OCT is superior to SD-OCT in imaging...
