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Journal Reviews

Ophthalmic Genetics cover picture

Patient reported outcomes in adolescents with inherited retinal diseases

4 October 2023 | Ian Reekie | EYE - Vitreo-Retinal | PROM, Patient-reported outcomes, clinical trial, gene therapy, inherited retinal disease, pediatrics, retinal dystrophy

This was a two-centre validation study of two sets of patient reported outcome measures (PROMS) for adolescents (13-17- years-old) with inherited retinal diseases. The measures were the Michigan Retinal Degeneration Questionnaire (MRDQ) and the Michigan Vision-Related Anxiety Questionnaire (MVAQ). Both...

Effects of ML4 on the eye

3 October 2023 | Fiona Rowe (Prof) | EYE - Paediatrics, EYE - Strabismus

Mucolipidosis type IV (ML4) is an autosomal recessive lysosomal storage disease and is caused by variants of the MC0LN1 gene. It often presents in young individuals with eye and ocular adnexa issues. The authors present a case report and literature...

Pain control during orbital implant surgery

3 October 2023 | James Hsuan | EYE - Oculoplastic, EYE - Orbit

This is a study based on existing evidence that pre-emptive pain control has advantages over traditional post-surgical analgesia. The authors compared pain scores in three groups of randomly assigned and masked patients all undergoing orbital implant surgery under general anaesthesia...

Neuro-Ophthalmology journal cover image

Narrative review of idiopathic intracranial hypertension in children / adolescents

3 October 2023 | Claire Howard | EYE - Neuro-ophthalmology | Adolescent, acetazolamide, intracranial pressure, paediatrics, papilloedema, pseudotumour cerebri

Idiopathic intracranial hypertension (IIH) affects both children and adults. Whilst the majority of IIH is mainly seen amongst adults, it also affects children. There are currently no clinical trials in IIH for those who are adolescents or children. The aims...

Neuro-Ophthalmology journal cover image

Agreeing terminology for non-classic visual field abnormalities

3 October 2023 | Lauren R Hepworth | EYE - Neuro-ophthalmology

The authors present a prospective survey of neuro-ophthalmologists. The survey comprised of 10 visual fields. The selection of visual fields for the survey aimed for variety and excluded classic neuro-ophthalmology visual field defects, e.g. hemianopia, nasal step. The survey was...

Surgical management and review of congenital inferior rectus dysgenesis

3 October 2023 | Fiona Rowe (Prof) | EYE - Paediatrics, EYE - Strabismus

Three cases are presented of congenital inferior rectus (IR) dysgenesis causing hypertropia. Case 1 was a two-year-old female with intermittent vertical strabismus of 20PD and -2 limitation on depression, worse in abduction. MRI imaging showed a hypoplastic IR. Following surgery,...

Brolucizumab in age-related macular degeneration, HAWK Study

3 October 2023 | Kurt Spiteri Cornish | EYE - Vitreo-Retinal | Neovascular age-related macular degeneration, aflibercept, anti-vascular endothelial growth factor therapy, brolucizumab, commercial formulation

The aim of the study was to collect additional data on efficacy and safety of brolucizumab 6mg intended for commercialization in age-related macular degeneration (AMD) (with an increase in pH and decrease in polysorbate concentration). The HAWK Study was a...

JAAPOS journal cover image.

Proof of concept for using aqueous humour to detect retinoblastoma variant

1 September 2023 | Lauren R Hepworth | EYE - Paediatrics, EYE - Strabismus

A proof of concept study is presented with the aim of assessing the feasibility of using aqueous humour surrogate marker for tumour tissue for identifying retinoblastoma RB1 variant. Three children undergoing enucleation for retinoblastoma were recruited from a single centre....

Long-term improvement of stereopsis in intermittent refractive esotropia

1 September 2023 | Fiona Rowe (Prof) | EYE - Paediatrics, EYE - Strabismus

This was a retrospective study to review the records of patients with refractive accommodative esotropia (RAET) to determine long-term stereoacuity (SA) improvement in those that showed initial poor or no stereopsis. The study included 79 patients; 54% male and mean...

ROP risk factors

1 September 2023 | Fiona Rowe (Prof) | EYE - Paediatrics, EYE - Strabismus

The purpose of this study was to evaluate the incidence and risk factors for retinopathy of prematurity (ROP) in two neo-natal units, and included a sub-analysis of infants with gestational age (GA) of ≥28 weeks. A retrospective review was undertaken...

Outcomes of adult new-onset strabismus presenting acutely

1 September 2023 | Fiona Rowe (Prof) | EYE - Paediatrics, EYE - Strabismus

This study evaluated causes, neuroimaging rates and results, and clinical courses of adults presenting to an ophthalmology emergency department with diagnosis of new-onset strabismus. This was a retrospective study of 557 adults (54.8% male) with mean age of 57.3 ±16.7...

Significant associations to presence of significant retinal haemorrhages in suspected child abuse

1 September 2023 | Fiona Rowe (Prof) | EYE - Paediatrics, EYE - Strabismus

The authors aimed to extract statistically significant associations between non-ocular clinical and diagnostic imaging findings and the presence of significant retinal haemorrhages, and then develop an evidence-based screening algorithm to determine when to consult an ophthalmologist in suspected child abuse...

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    Fiona Rowe (Prof)

    Professor of Orthoptics

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