You searched for "melanocytes"
Limbal melanocytes and the stem cell niche
The cornea is continually regenerated to maintain clear vision, due to a population of stem cells located in the limbal region between the cornea and the conjunctiva. These limbal stem cells (LESC) reside in crypts in structures called the Pallisades...Melanocytoma of the optic disc
Melanocytoma is a heavily pigmented lesion, composed of melanocytes and is a variant of melanocytic naevus. It classically occurs at the optic disc and is usually benign, static and asymptomatic. However, it can occasionally grow and invade the retina or...
A mouse model for uveal melanoma
Uveal melanoma (UM) is the most common malignant tumour arising within the eye and is a severe threat for both sight and life, due to a high risk of metastasis. There are no animal models of UM, but the Tg(Grm1)...
Diffuse lamellar keratitis
This study group reviewed cytokine- and chemokine-mediated mechanisms of diffuse lamellar keratitis (DLK) after lamellar corneal surgical procedures. DLK can occur early or late (months to decades) after all lamellar corneal surgeries, including laser in situ keratomileusis, small incision lenticule...
Stromal cell alignment in damaged cornea
Stromal keratocytes are responsible for wound healing in the cornea following damage. Keratocytes at the site of injury become activated and differentiate to myofibroblasts which secrete extracellular matrix (ECM) to close the wound, a response mediated by transforming growth factor...
Late stromal rejection in DALK
This case series reported on late stromal rejections in eyes after uncomplicated deep anterior lamellar keratoplasties (DALKs). Four eyes of three patients experienced episodes of isolated stromal rejection 33 to 46 months after surgically uncomplicated DALKs and a minimum of...
Suspected vitreous seeding of uveal melanoma
This is a retrospective non-randomised study of 23 patients with consecutive uveal melanoma who underwent diagnostic vitrectomy between the period of January 2000 and November 2013. The reason for vitrectomy was suspected dissemination of tumour cells inside the eye. The...
Presentation of conjunctival intraepithelial neoplasia
Ocular surface squamous neoplasia is the umbrella term for malignancies of the conjunctiva and within the spectrum lies conjunctival intraepithelial neoplasia (CIN) – a non-invasive malignancy. CIN has been implicated with ageing, smoking and ultraviolet light exposure. The typical manifestation...Sensitive cilia – eyelashes in health and disease
In health our eyelashes protect the eyes, but in disease they can disfigure, impair quality of life and threaten vision. In this review the authors discuss aspects of lashes that are relevant to all professionals working near the eyes and...“Beware of the pigment”
Using some captivating artwork, Iheukwumere Duru describes key features of pigment dispersion syndrome. Pigmentary dispersion syndrome (PDS) leads to pigmentary glaucoma (PG) in approximately 35-50% of patients with the condition [1]. PG is the leading cause of non-traumatic blindness in...
Corneal lenticule allotransplant
This animal study looked at corneal lenticule allograft transplantation in rabbits. Seven rabbits underwent small incision lenticule extraction (SMILE) procedures, where their stromal lenticules were extracted and transplanted fresh into pre-prepared corneal stromal pockets of seven recipient eyes. Animals were...
