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A case report of visual loss as a consequence of coeliac disease
The authors present a case of permanent visual loss secondary to occipital lobe calcification in coeliac disease, the first reported such case. The 58-year-old man had been diagnosed with coeliac disease 20 years prior to his visual investigations and had...
Selection of visual field test for detection of pituitary disease
This prospective cross-sectional diagnostic accuracy study compared Octopus semi-automated kinetic perimetry (SKP) and Humphrey static automated central perimetry for detection of neurological visual field loss in patients with pituitary disease. Humphrey central 30-2 SITA threshold programme results were compared with...
Visual field changes in thyroid eye disease (TED)
This study is a retrospective non- comparative review of visual field (VF) tests in patients with compressive optic neuropathy from thyroid eye disease (TED-CON). Ninety-six visual fields in 68 patients were included in the study and a two-step analysis of...
Ophthalmic presentations and outcomes in Erdheim-Chester disease
This is a comprehensive article describing clinical manifestations and pathogenesis of Erdheim-Chester disease (ECD) followed by a literature review of the available treatments. The authors look to compare historical treatment (HT) with vemurafenib, a BRAF inhibitor. ECD is a non-Langerhans...Effective management of dry eye and ocular surface disease
Experts recommend a consistent approach to diagnosis, therapeutic targeting by disease subtype and escalation of therapy when tear substitutes are not sufficient. Experts call for a consistent, unified approach to diagnosis of dry eye disease (DED), with a new simple...
Natural regression of brow heaviness in thyroid eye disease
This is a retrospective review of the change over time in the sub-brow fat volume in 104 patients with thyroid eye disease. Standardised photographs taken at diagnosis were compared with those taken after an average period of 10 years (+/-...
Incomplete teprotumumab treatment for thyroid eye disease
This is a multi-centre retrospective analysis of clinical outcomes in patients who were on teprotumumab for thyroid eye disease but had the usual regime of eight infusions, three weeks apart, interrupted due to COVID-19. Manufacturing was suspended between Dec 2020...
Tear production levels and dry eye disease
Dry eye disease (DED) is multifactorial, caused by an alteration in the quality or quantity of tear film’s three layers. Several tests are available for diagnosis. The aim of this study was to determine if the Schirmer test (ST) could...
A case series of acquired esotropia in cerebellar disease
Acquired esotropia in cerebellar disease is well described but under-recognised. The pathogenesis of cerebellar esotropia is controversial. It is suggested it may be a result of disruption to central vestibular pathways. This article reports a case series of seven adults...
No risk of dry eye disease in concomitant strabismus cases
This preliminary assessment of the ocular surface of patients with concomitant strabismus before surgery was undertaken to determine if the presence of strabismus increases the risk of dry eye disease. This was a cross-sectional study of 204 patients with concomitant...Exploiting nature’s randomised trials of eye disease
Confounding and reverse causation in observational ophthalmic epidemiology Traditional observational studies are inherently limited in establishing a causal effect of an exposure on an outcome of interest. One fundamental limitation is confounding, whereby causation is incorrectly attributed to a third...
