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My COVID-19 songs

A portrait of Anna by Tamara Jovandic-Everson as part of #portraitsforNHSheroes. I am a consultant eye surgeon and these are my COVID songs. First of all, I have not even had time to digest the past six months, partly because...

Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells

There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...

Electrocautery and implantable cardiac devices

This is a literature review of the risks associated with bipolar and monopolar electrocautery in patients with a permanent pacemaker (PPM) or implantable cardioverter defibrillator (ICD). The authors found 12 publications which met their inclusion criteria, but within these there...

Changing operating room practices: the effect on postoperative endophthalmitis rates following cataract surgery

This is a retrospective clinical registry study from India of 85,552 cataract surgery patients; group 1 (56,551 patients from January-March 2020) and group 2 (29,011 patients from May-August 2020). Group 1’s patients were ungowned, surgical gloves were disinfected but not...

Is serum ACE useful in diagnosing sarcoidosis in uveitis patients?

This retrospective clinical notes review assesses whether serum angiotensin converting enzyme (ACE) is useful in the diagnosis of sarcoidosis in patients presenting with uveitis. There were 1035 consecutive subjects presenting with uveitis as part of baseline investigations had a serum...

Comparison of retinal pigment epithelium-choroid graft surgery and anti-VEGF therapy in patients with wet AMD

This was a randomised intervention study in wet AMD patients to investigate benefits of free RPE-choroid graft transplantation surgery versus (continuation of) anti-VEGF treatment. Twenty patients who met the inclusion criteria were subdivided into three subgroups, i.e. RPE tears involving...

Ginko bilboa extract affects hypoxic retinal pigment epithelial cells

Wet age-related macular degeneration (AMD) is characterised by choroidal neovascular membrane (CNVM) formation. It is thought that localised hypoxia within the retina results in overexpression of growth factors such as vascular endothelial growth factor (VEGF), which induces CNVM formation. VEGF...

Management of giant retinal tears with vitrectomy and perfluorocarbon liquid postoperatively as a short-term tamponade

The authors report an eight year retrospective case series study of 30 eyes of 29 patients with who underwent a giant retinal tear-related retinal detachment repair. M: F ratio was 23:6. Right to left eye ratio was 16:14. The mean...

The treachery of images – making sense of OCT imaging

In 1929 Belgian surrealist Rene Magritte produced his painting La Trahison des Images. It depicted an old fashioned pipe for smoking tobacco and underneath were the words “ceci n’est pas une pipe”, this is not a pipe. You may wonder...

Air toxicity on retinal pigment epithelium

This study investigated the potential toxic effects of air on primary human retinal pigment epithelial (RPE) cells in vitro. Clinically during pars plana vitrectomy air is used as either a temporary tamponade during air-fluid exchange or mixed with gas to...

Endophthalmitis after intravitreal anti-VEGF injection

The authors report the results of a retrospective multicentre study conducted at 17 retina referral centres to investigate the microbial spectrum of endophthalmitis after anti-VEGF injections. A total of 83 cases of culture-positive endophthalmitis (58.4%) were included. The most frequent...

SCONe Project seeks participants for patient and public involvement group to revolutionise AMD research

The SCONe project, run by optometrists, ophthalmologists, and researchers from the University of Edinburgh, and funded by Sight Scotland, is appealing for participants to take part in a Patient and Public Involvement (PPI) group focused on revolutionising the detection and management of Age-Related Macular Degeneration (AMD).