Journal Reviews

Glaucoma medications and ocular surface disease

3 August 2023 | | Glaucoma | Drug allergy, OSD, drug toxicity, drug-induced cicatricial keratitis, dry eye, glaucoma medications, ocular surface disease

This literature review examined ocular surface disease (OSD) associated with glaucoma medication. The authors examined the prevalence of features and management guidelines glaucoma medication associated OSD. Fifty-eight articles published within the past five years are included in this review and...

Diplopia after cataract surgery – risk factors

1 June 2022 | | Paediatric Ophthalmology / Strabismus | anesthesia, cataract surgery, diplopia, myotoxicity, strabismus

The risk factors for binocular diplopia after uncomplicated cataract surgery in adults were studied to analyse the patterns of ocular motility and clinical causes. This was a retrospective review of 40 patients; 25 female. Onset of diplopia was at a...

Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells

1 October 2016 | | Retina / Uvea / Vitreous | chemotherapy, intra-ocular tumour, retinal pigment epithelium, retinoblastoma, toxicity

There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...

Bitemporal hemianopsia as a result of ethambutol toxicity

1 October 2016 | | Neuro-Ophthalmology | Bitemporal, Mycobacterium, ethambutol, hemianopsia, toxicity

The authors present six cases of visual loss in patients treated with ethambutol for mycobacterium avium complex, including four patients with bitemporal hemianopsia. Two additional patients were undergoing glaucoma monitoring and developed visual field defects with ethambutol treatment, which recovered...

Air toxicity on retinal pigment epithelium

1 August 2015 | | Retina / Uvea / Vitreous | Air toxicity, internal gas tamponade, pars plana vitrectomy, pneumoretinopexy, retinal pigment epithelium

This study investigated the potential toxic effects of air on primary human retinal pigment epithelial (RPE) cells in vitro. Clinically during pars plana vitrectomy air is used as either a temporary tamponade during air-fluid exchange or mixed with gas to...

Optical coherence tomography in patients exposed to vigabatrin

1 August 2014 | | Retina / Uvea / Vitreous | anti-epileptic drug, drug toxicity, full-field electroretinography, optical coherence tomography, vigabatrin, visual field defect

Vigabatrin is used to treat epilepsy and can lead to increased levels of gamma-aminobutyric acid (GABA) in the brain and in the retina leading to binasal visual field defects. Although not the first line of treatment for adults it is...