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Breakthroughs in the genetics of angle-closure glaucoma

Angle closure glaucoma (ACG) is not widely known to be a familial condition, yet the recent explosion of genetic data and large scale genome wide investigations have confirmed at least 13 genetic loci associated with ACG [1], and provided some...

An update on inherited retinal disorders (part 2): Approaches to therapy for IRDs

Part 1 of this topic can be found here There are currently no proven cures for inherited retinal disease (IRD). However, multiple avenues of research are being investigated to better understand disease mechanisms and trial potential therapies that may slow...

Redefining healthcare through the eyes

The future of healthcare is being shaped by innovation in eyecare and in particular a field known as oculomics. This discipline leverages ocular biomarkers to provide insights into various health conditions, including cardiovascular diseases and psychological or neurological disorders [1]....

Personalising the management of dry eye disease: TFOS DEWS III updates evidence-based recommendations

Dry eye disease (DED) is a heterogenous condition that arises from various aetiologic factors and leads to tear film instability, ocular surface damage and neurosensory changes. Symptoms of DED include ocular dryness, burning, itching, pain and visual impairment. An evidence-based...

The role of inflammation in the pathophysiology of DMO

Diabetic macular oedema (DMO) is a major cause of visual loss in diabetes, with a complex multifactorial pathogenesis. In the UK alone it is estimated that there are nearly 2.5 million diabetic patients aged over 12 years. Approximately 65,000 of...

What’s new in wet AMD papers?

Paper presentations on neovascular (‘wet’) age-related macular degeneration (AMD) from the 16th European Society of Retina Specialists Congress, Copenhagen, September 2016, outline recent research directions evaluating the impact of vision loss on key health domains, patient preferences in the process...

Introduction of the Mydriasert insert at the Manchester Royal Eye Hospital

The authors report on a study to examine the effects of the Mydriasert insert on time, effects, patient comfort and tolerability at Manchester Royal Eye Hospital. Mydriasert is an insoluble ophthalmic insert indicated for mydriasis prior to ophthalmic surgery, which...

IN FOCUS - The achievements and lasting effects of VISION 2020

Blindness is a major public health problem globally. The first estimate of global blindness by the World Health Organization (WHO) in 1972 provided a figure of 10 to 15 million, which was considered an underestimate [1]. In 1999, an extraordinary...

From monofocal to premium: Understanding the expanding landscape of intraocular lenses

For many years cataract surgery was framed almost entirely as a restorative procedure. The goal was straightforward: remove the cloudy lens and replace it with a clear one, restoring distance vision and allowing the patient to function comfortably with reading...

VISION 2020 LINKS Programme: the Madagascar-Leeds LINK

Madagascar is a fascinating and culturally rich island which has an ‘exotic’ status in most people’s eyes. Yet it is among the poorest countries in the world. According to the World Bank, 92% of the population live on less than...

25 years of OCT

David Huang first described optical coherence tomography (OCT) in 1991, in his seminal paper on the subject in Science. This method developed the work of others on ophthalmic interferometry, which essentially showed that measuring reflected light could be used to...