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Renewed momentum in ocular gene and cell therapy, broadening application to chronic disease
Gene and cell therapies offer the prospect of ground-breaking new avenues for the treatment of diseases, reflected in a renewed explosion of interest and investment in retinal gene therapy. Rod McNeil reports recent clinical trial readouts across a diverse range...Discussing treatment modalities for bilateral wet AMD
A 65-year-old lady with bilateral wet AMD and vision of 6/24 comes with an internet search about current therapies. How do you explain the various treatment modalities available? There are two NICE approved treatments for wet age-related macular degeneration (AMD)....Serendipity
“Serendipity is looking in a haystack for a needle and discovering a farmer’s daughter” – Julius Comroe Jr (Surgeon, Medical Researcher and Author) One of the attractive features of ophthalmology, apart from the good quality of life and the relatively...What's trending Aug/Sep 2024
A round-up of the eye-related hot topics that have been trending on social media over the last few weeks. #GeneralElection #RightToVote It goes without saying that the general election has been dominating the headlines and with it, the challenges many...Effect of minor trauma in eyes with previously undiagnosed angioid streaks
Angioid streaks (AS) may be associated with pseudoxanthoma elasticum (PXE), Paget’s disease, haemoglobulinopathies, Ehlers-Danlos Syndrome or abetalipoproteinaemia. Histopathology showed retinal pigment epithelium (RPE) and choriocapillaris loss, elastic fibre degeneration, calcium deposition, active choroidal neovascular membrane (CNVM) and vascular endothelial growth...Nanosecond laser cataract surgery
The authors review the evidence for nanosecond laser cataract surgery: is this the future? Cataract is a leading cause of visual impairment worldwide, and cataract surgery is one of the most successful and cost-effective healthcare interventions, with a great impact...The Leicester Grading System for Foveal Hypoplasia
The University of Leicester Ulverscroft Eye Unit have published the first medical grading system named after the city of Leicester. Infantile nystagmus is characterised by constant and involuntary eye movements and affects 24 per 10,000 people [1]. Onset is usually...DMEK vs. UT-DSAEK: has the debate been finally concluded?
In recent years the surgical treatment of corneal endothelial dystrophy has progressed tremendously. Descemet’s membrane endothelial keratoplasty (DMEK) is the newest iteration in the line of rapid surgical advances that has taken place. However, the previously accepted gold standard prior...Rare eye diseases: progress continues with authorised orphan medicines and breakthrough technologies
An update on the development of orphan medicines, recent regulatory treatment approvals for rare eye conditions and advances in retinal prosthetic technologies for blinding diseases. The prevalence of a rare disease is based usually on a range of estimates and...The past and the future for paediatric ophthalmology
The past 25 years have seen remarkable advances in clinical eye care for children in the UK. This has led to both improved outcomes and better patient and family experiences. There have been substantial changes to patient pathways, major advances...Genetic profiling for personalised healthcare solutions in AMD – an update
Age-related macular degeneration (AMD) is a multifactorial condition influenced by genetics and lifestyle factors (Table 1). This article outlines several recent advances in AMD genetics, as well as evolving therapeutic concepts and established practical measures for the treatment and /...
