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Corporate M&A pace gathers momentum

Intensifying franchise competition, maturing product development pipelines and looming loss of exclusivity spur renewed merger and acquisition (M&A) activity in the ophthalmics sector. Rod McNeil reviews recent deals and related strategic developments. AbbVie to acquire Allergan in $63 billion mega-combination,...

The results of the last survey Feb24

Thank you to all those who participated in this edition’s survey and for those of you who attended my recent Medico-legal Seminar at the Royal College of Ophthalmologists. It was a fascinating and educational day, made a success by the...

Birdshot retinochoroiditis

Birdshot retinochoroiditis (BRC) is a chronic, sight-threatening uveitis, most commonly affecting caucasian individuals in their fourth to sixth decades [1]. The disease is associated with HLA-29 and is characterised by progressive inflammation at the level of retina and choroid, with...

New developments

To reflect the fact that this column consists of not just web links, but also mobile and general technology content we have changed the name from Internet to ‘Tech Review’. In keeping with the title, this issue includes a mixture...

Lines, dots, spots and rings in ophthalmology: understanding eponyms

Eponymous names are familiar to all who have undergone undergraduate and postgraduate training in medicine. The ability to name a few allows one to stand out among your peers and rare, or not so rare, eponymous syndromes are a favourite...

Conference Preview: UKISCRS, UKISOP and YOP 2025

London’s calling, and we will be rejoining the United Kingdom & Ireland Society of Cataract & Refractive Surgeons (UKISCRS), the Young Ophthalmologists Programme (YOP), and United Kingdom & Ireland Society of Ophthalmic Practitioners (UKISOP) between 12–14 November. The former will...

Shedding light on Wolfram syndrome: The unveiling of a delayed diagnosis

Wolfram syndrome 1 (WS1) was first described by Wolfram and Wagener in 1938 and it’s a rare neurodegenerative, progressive disorder, also known as DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness) [1]. We present an atypical case of WS...

What’s new in glaucoma? Clinical trials drive practice changes, surgical advancements gather pace

Rod McNeil reviews the latest developments in the treatment of glaucoma in the UK. Primary open-angle glaucoma (POAG), which accounts for over two-thirds of all glaucoma cases, has an estimated UK prevalence in 2017 of approximately 2% of people over...

My top five eye-related webinars during lockdown

1. Alcon Experience Academy The Alcon Experience Academy ran a non-promotional educational series from 12 May to 23 June 2020. Being mildly biased as a junior trainee, this has to be rated by far the best series due to its...

My Top Five: Eye-related webinars during lockdown

1. Alcon Experience Academy The Alcon Experience Academy ran a non-promotional educational series from 12 May to 23 June 2020. Being mildly biased as a junior trainee, this has to be rated by far the best series due to its...

Exploiting nature’s randomised trials of eye disease

Confounding and reverse causation in observational ophthalmic epidemiology Traditional observational studies are inherently limited in establishing a causal effect of an exposure on an outcome of interest. One fundamental limitation is confounding, whereby causation is incorrectly attributed to a third...

RTP801 as a neuroprotective and axon regenerative treatment

This paper describes the neuroprotective and axon regenerative effects of siRTP801, which is a translatable small-interfering RNA (siRNA) targeting mTOR negative regulator; RTP801, through in-vivo and in-vitro models. In-vivo studies involved an optic nerve crush rat model with intravitreal injections...