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Leber’s hereditary optic neuropathy: from lab to clinic

1 October 2016 | | EYE - Neuro-ophthalmology | Hereditary optic neuropathy, Leber hereditary optic neuropathy, mitochondrial optic neuropathy, optic neuropathy
Leber’s hereditary optic neuropathy (LHON) was the first clinically described mitochondrial disorder (1871). This article reviews the pathophysiology and clinical features of LHON with a focus on translational research. G11778A is currently the most common mutation worldwide and is associated...

Detecting apoptosis in retinal cells

1 February 2022 | | EYE - Vitreo-Retinal | Apoptosis, Glaucoma, Imaging, Neurodegeneration, Retina
This is a review paper in which the authors summarise the transitioning of techniques detecting apoptosis from bench to bedside, along with the future possibilities they encase. Detection of Apoptosis in Retinal Cells (DARC) technology can be used as a...

The science of glaucoma management: highlights of the 2020 Moorfields International Glaucoma Symposium

5 October 2020 | | EYE - Glaucoma, EYE - General
Held earlier this year, the 12th annual Moorfields International Glaucoma Symposium provided a forum for advanced clinical and scientific exchange in glaucoma management. The authors describe the key presentation themes and debates, highlighting specific topics of interest to glaucoma specialists....

When science meets art: Creating brilliant sparks

4 February 2025 | | EYE - Glaucoma
I was honoured to have the privilege of reconnecting with the Tongren Eye Center team in Beijing, China. Digital art in mainstream media has showcased some glorious works and it is humbling to see and hear about some creative new...

What's trending Feb/Mar 2021

4 February 2021 | | EYE - General, EYE - Cornea, EYE - Orbit, EYE - Vitreo-Retinal
A round-up of the eye-related hot topics that have been trending on social media over the last few weeks. Happy New Year! Goodbye 2020, a year no one could have imagined, with our lives and headlines dominated by COVID-19 as...

Don’t ignore the black lesion! It might be mucormycosis

1 June 2017 | | EYE - Cornea
Keeping mucormycosis infection in the foreground of your differential diagnosis, especially in those more vulnerable patients, will help save their lives if recognised and managed appropriately. Mucormycosis is a fulminant infection caused by the fungi of the family Mucoraceae. It...

Neuro-ophthalmic disease patterns in Southeast Asia with particular reference to giant cell arteritis

1 April 2016 | | EYE - Neuro-ophthalmology
As indicated in an earlier article in Eye News [1] Dr Cullen was invited in 2000 to the Singapore National Eye Centre (SNEC) as visiting Professor with a specific remit to set up a specialist neuro-ophthalmology service, which was the...

Letter from America: Orbit and oculoplastic fellowship, University of California, San Diego

1 June 2014 | | EYE - Oculoplastic, EYE - Orbit
I was the fortunate recipient of the 2012 Keeler Scholarship, granting me the incredible opportunity to undertake a fellowship at the University of California, San Diego (UCSD) in orbital, oculoplastic and reconstructive surgery. My fellowship mentors were the renowned Professor...

Brain tumours in adults: the essentials for an ophthalmologist

1 August 2019 | | EYE - Neuro-ophthalmology, EYE - General
The author provides a review of the common intracranial tumours in adults (other than pituitaries) which may present to an ophthalmologist. Primary malignant brain tumours comprise 3% of adult cancers but with an ageing population such tumours are becoming more...

Understanding spaceflight-associated neuro-ocular syndrome (SANS): what do we know?

2 August 2022 | | EYE - Oculoplastic, EYE - General
Introduction Formerly known as visual impairment and intracranial pressure syndrome (VIIP), space-related neuro-ocular syndrome (SANS) is defined by a collection of ophthalmic and neurological findings in astronauts after long-term spaceflight [1]. Changes in the eyeball, such as hyperopic shift, during...

Ophthalmology history and examination – a guide for medical students

15 February 2023 | | EYE - General
*First author Students have very little exposure to ophthalmology during their years at medical school. Teaching consists of a handful of lectures followed by a short placement in which students are expected to practise histories and examinations on patients with...

The Sickle Cell Retinopathy Network is leading global change in screening and management

2 October 2025 | | EYE - Vitreo-Retinal
Sickle cell disease or disorder (SCD) is one of the most neglected health conditions in the world. A strong hypothesis is that this is because SCD affects people of African, Caribbean and other Global Majority communities and has received disproportionately...