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Gene therapy for inherited retinal disease: the Manchester Ocular Gene Therapy Group MDT service
The authors describe the process set up in Manchester for the optimum delivery and assessment of a new gene therapy treatment for patients with RPE65 IRD. Inherited retinal dystrophies (IRDs) are the second commonest cause of severe visual impairment in...Tackling diabetic retinopathy globally through the VISION 2020 LINKS Diabetic Retinopathy Network
It is abundantly clear that the burden of diabetes is rapidly increasing, as there are now 415 million adults with diabetes in the world, with a projected rise to 642 million by 2040 [1]. This equates to 1 in 10...How to get a trainee from 0 to 600 cataracts in two years: Perspectives from the trainee and the trainer
Trainee’s perspective I remember my first day as an ST1 at Moorfields Eye Hospital in Croydon. I was in theatre for a cataract list, and the challenges were numerous. From draping to hydrating the wound, it was all completely new...Deliberate darkness: The systematic weaponisation of blinding in global protests
As eyecare professionals, we spend our entire professional lives fighting to preserve light. We train to master the delicate microscopic topography of the cornea, the retina and the optic nerve, all with the objective of saving our patients from the...Meltdown, Spectre, Flying Hospitals and Spy Cams
iPhone slowdown In early 2018 users discovered that Apple was slowing down older iPhones intentionally. The reported reason was to prolong the usable battery life. These changes were made without the knowledge or consent of owners. Unsurprisingly, a community backlash...Hot debates in medical retina and imaging: Perspectives from the Controversies in Ophthalmology 2020 virtual conference
Controversies in medical retina and imaging were debated during the Controversies in Ophthalmology 2020 virtual conference held during two mid-day scientific sessions on 27 and 28 March 2020. The author recounts key perspectives and presents viewpoint recommendations from the Vision...
Posterior capsular rupture risk factors as reported in the European registry
In this cross-sectional review of the European Registry of Quality Outcomes for Cataract and Refractive Surgery (EUREQUO) including 2,853,376 patients and 31,749 cases with posterior capsular rupture (PCR), the authors observed a trend of reduction in PCR rate from 1.44%...
The natural history of treatment naïve choroidal neovascularisation (CNV) in geographic atrophy
The aim of this retrospective study is to assess the characteristics and natural history of quiescent CNV in geographic atrophy (GA) utilising multi-modal imaging. Case notes were reviewed of patients diagnosed with geographic atrophy between January 2010 and December 2016...
Visual prognosis in Irish Leber’s hereditary optic neuropathy
Leber’s hereditary optic neuropathy (LHON) is an inherited optic neuropathy This paper presents a retrospective review of clinical data from patients with LHON presenting to an Irish tertiary referral ophthalmic hospital. Clinical and genetic characteristics were assessed for useful biomarkers...The invisible touch: a VISION 2020 LINK with Indonesia
Indonesia’s population, the world’s fourth largest, is spread across 6,000 inhabited islands. Whilst some areas (e.g. Kalimantan, Papua) are relatively sparsely populated, Java is the world’s most densely populated island, with twice the population of the UK in half the...
Silicone oil migration presenting as an eyelid cyst
The author presents a single case report of a rare complication of silicone oil tamponade, silicone oil migration, after pars plana vitrectomy. A seven-year-old female, with a history of vitrectomy one year prior for penetrating eye trauma, presented with a...
