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Idebenone for Leber hereditary optic neuropathy

The authors present a meta-analysis of studies reporting the effects of idebenone treatment on visual acuity (VA) in patients with Leber hereditary optic neuropathy (LHON), the most common inherited mitochondrial disorder. They included randomised controlled trials, non-randomised controlled trials and...

Reclassifying genetic variants in inherited retinal diseases

The authors present a retrospective study of 142 gene sequence variants from 28 patients with vitreoretinal dystrophies which were re-interpreted based on American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP) guidelines. Overall, there was...

Clinical characteristics and visual outcome of patients with macular pseudohole

This is a retrospective study of consecutive patients with macular pseudohole (MPH) who had vitrectomy and were followed for at least 6 months postoperatively. MPH was diagnosed based on spectral-domain optical coherence tomography (OCT) findings. 76 eyes of 75 patients...

Eye Emergency Study Day for Doctors

Join us for a dynamic, hands-on study day designed to strengthen your confidence and skills when dealing with ophthalmic emergencies. This interactive day combines theoretical learning working through clinical scenarios, ensuring you leave equipped to oversee the initial management of...

Orbital cellulitis - an overview of the diagnosis and management

Periorbital (preseptal) and orbital cellulitis are infections of the subcutaneous tissues of the eye. They are differentiated by the location of the infection. Periorbital cellulitis refers to infection of the eyelid and subcutaneous tissues anterior to the orbital septum, whereas...

Robotic assisted orbital surgery (RAOS) – a novel approach to orbital malignancy surgery

Robotic technology in ENT surgery has been used in certain areas of head and neck cancer care but, in this article, we hear of an exciting development from the team at Guy’s & St Thomas’. Advances in surgical robotic technology...

From trainee to teacher: Top tips for teaching fellow applications

Getting into ophthalmology training has become increasingly competitive in recent years. In 2025, the competition ratio rose to over 21:1, compared to 3:1 in 2019 [1,2]. Similar trends are seen across other specialties, with over 30,000 doctors applying for just...

Myopia management

With the growing prevalence of myopia at epidemic levels in some countries and increasing number of research publications on myopia control, there is a lot of controversy regarding the management of myopia. As none of them are at present available...

The eye as a window to the brain: Non-invasive neuromonitoring

This article has been verified for CPD. Click the button below to answer a few short questions and download a form to be included in your CPD folder. Neuromonitoring, for example in conditions causing raised intracranial pressure (ICP) such as...

What's trending Feb/Mar 2022

A round-up of the eye-related hot topics that have been trending over the last few weeks. British man fitted with 3D printed eye Steve Verze of London has required a prosthetic eye for over 20 years. On 25 November 2021,...

The results of the last survey Aug21

We are often referred patients noted to have an optic disc haemorrhage (ODH) without any other features of pathology. How we manage these patients can have a significant impact on our struggling capacity. The significance in glaucoma and, in particular,...

A step-by-step approach to the diagnosis and management of Sands of Sahara Syndrome

Sands of Sahara syndrome (diffuse lamellar keratitis) is a rare postoperative complication of Laser in situ keratomileusis (LASIK). Its estimated prevalence is reported to be 2-4% among LASIK cases [1], despite that, it is more likely to be encountered by...