This is a retrospective study of consecutive patients with macular pseudohole (MPH) who had vitrectomy and were followed for at least 6 months postoperatively. MPH was diagnosed based on spectral-domain optical coherence tomography (OCT) findings. 76 eyes of 75 patients were included with overlapping cases of MPH + epiretinal membrane foveoschisis (ERM FS), 17 eyes; MPH + Lamellar hole (LMH), 18 eyes; and MPH + ERM FS + LMH, 3 eyes. Preoperative best corrected visual acuity (BCVA) and the presence of epiretinal proliferation showed significant associations with worse postop BCVA (p<0.0005 and P<0.05 respectively). Presence of ellipsoid zone disruption at 3 and 6 months postoperatively was associated with worse BCVA (p<0.0001 and p<0.01 respectively).

