Journal Reviews

Acute retinal necrosis: an Indian experience

1 August 2014 | | Ocular Pathology and Oncology | Acute, India, clinical features, management, outcome, retinal necrosis

The authors of this retrospective study aimed to provide clinical outcomes in 62 eyes of 53 patients presenting with acute retinal necrosis. All eyes received intravenous acyclovir (10mg/kg tds) for 7-10 days followed by oral antiviral therapy (valaciclovir 1g tds...

Spectral domain OCT vs. confocal scanning laser ophthalmoscope in measuring RNFL thickness

1 June 2014 | | Ophthalmology | Cirrus optical coherence tomography, Heidelberg retinal tomograph 3, retinal nerve fibre layer thickness

The aim of this prospective study was to compare the retinal nerve fibre layer thickness (RNFL) measurements obtained from the Cirrus optical coherence tomography (spectral domain OCT) with the Heidelberg Retinal Tomograph 3 (HRT3, confocal scanning laser ophthalmoscope). Eighty-eight normal...

New mouse model of diabetes mellitus

1 April 2014 | | Retina / Uvea / Vitreous | aldose reductase, cell signaling P-ERK1/2, P-SAPK/JNK, P-Akt, diabetic rats, diabetic retinopathy, green fluorescent proteins, growth factors VEGF, bFGF, TGF-β, retinal vascular changes, transgenic diabetic mouse models

Diabetic retinopathy (DR) is a serious complication of diabetes. It is driven by the loss of pericytes, cells which control vascular function, due to excess formation of sugar alcohols by the enzyme aldose reductase (AR). AR has been shown to...

Ocular characteristics in Marfan syndrome

1 February 2014 | | Cataract and Refractive | Marfan syndrome, aphakia, axial length, cataract, ectopia lentis, flattened cornea, myopia, pseudophakia, retinal detachment

Marfan syndrome (MFS) is a genetic disorder with clinical manifestations associated with cardiovascular, ocular and skeletal organ systems. Typical signs are descending aortic root aneurysms, ectopia lentis, tall stature and scoliosis. This observational study looked at the ocular characteristics, visual...

Density of cataract and its influence on retinal nerve fibre layer thickness

1 December 2013 | | Retina / Uvea / Vitreous | cataract, image quality, optical coherence tomography, retinal nerve fibre layer

The aim of this study was to further define and model the influence of cataract on spectral domain optical coherence tomography (SDOCT) image quality and retinal nerve fibre layer (RNFL) thickness measurements. OCT quality is influenced by opacities in the...