Visual outcomes after surgery for primary rhegmatogenous retinal detachment in era of microincision vitrectomy
This is a prospective, multicentre, nationwide study between 2016 and 2017, to investigate the preoperative ocular factors, surgical techniques (pars plana vitrectomy (PPV) or scleral buckling (SB), or combined procedures) for rhegmatogenous retinal detachment (RRD) and postoperative best corrected visual...
The effects of anti-VEGF therapy for NvAMD on retinal vasculature
4 August 2021
| Su Young
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EYE - Vitreo-Retinal
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aflibercept, foveal avascular zone, neovascular age-related macular degeneration, ranibizumab, retinal vessel density
This retrospective consecutive case series examined 54 eyes of 54 treatment-naïve neovascular age-related macular degeneration (N-AMD) patients. Thirty-three eyes received intravitreal aflibercept injections, and 21 eyes received intravitreal ranibizumab injections with unaffected fellow eyes (54 eyes) as controls. All image...
Suture-less flanged IOL fixation vs. conventional sutured SF in IOL dislocation
3 June 2021
| Sofia Rokerya
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EYE - Cataract, EYE - Refractive
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Intraocular lens dislocation, Sutureless flanged fixation, Vitrectomy, Vitreoretinal surgery
The authors report the analysis of a prospective, comparative cohort study on 103 consecutive patients (103 eyes) with intraocular lens (IOL) dislocation who underwent vitrectomy with IOL removal and sutured scleral fixation (SF) (53 eyes) or flanged IOL fixation (50...
Relationship between intraocular pressure and optic nerve damage in optic nerve drusen
7 April 2021
| Claire Howard
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EYE - Neuro-ophthalmology
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Optic nerve head drusen, intraocular pressure, retinal nerve fibre layer, visual field
The authors present a retrospective study exploring the relationship between intraocular pressure (IOP) and optic nerve damage in patients with optic nerve drusen. The aim was to evaluate if patients with normal ocular pressure at the time of optic nerve...
Does Ozurdex affect perfusion status in vein occlusion?
1 October 2018
| Eulee Seow
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EYE - Cataract, EYE - Refractive
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intravitreal dexamethasone implant, peripheral nonperfusion, retinal vein occlusion, wide-field fluorescein angiography
Ozurdex (intravitreal dexamethasone implant) has been approved by National Institute of Health & Care Excellence (NICE) for treatment of patients with macular oedema associated with vein occlusion. This study looks at the change in peripheral perfusion status in patients with...
Intraocular surgical training – is there any inter-procedural transfer of skills?
1 June 2018
| Eulee Seow
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EYE - Cataract, EYE - Refractive
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assessment/formative feedback, cataract surgery, simulation-based training, vitreoretinal surgery
Cataract surgery is the most commonly performed surgery during ophthalmology training. This study aims to investigate how experience in simulated cataract surgery impacts and transfers to the learning curves for novices in vitreoretinal surgery. Twelve ophthalmology residents without previous experience...
Association between colour vision impairment and amyotrophic lateral sclerosis (ALS)
1 April 2018
| Claire Howard
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EYE - Neuro-ophthalmology
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Amyotrophic lateral sclerosis, colour vision, desaturated L’Anthony D-15, retinal disease
The purpose of this study is to test the hypothesis that colour vision impairment is associated with amyotrophic lateral sclerosis (ALS). Abnormalities of the inner and intermediate retinal structures in patients with ALS have been described using optical coherence tomography...
Comparison of visual fields between migraine and tension type headaches
1 August 2017
| Claire Howard
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EYE - Neuro-ophthalmology
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Migraine, retina, aesthetic surgery, visual field
The aim of the study was to compare the clinical features and visual fields of patients with migraine without aura and tension type headache. Visual fields were assessed whilst the patients were having an attack of pain and tested using...
Histopathological changes in rabbit retinitis pigmentosa
1 April 2017
| Claire Howard
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EYE - Neuro-ophthalmology
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Optic disc, optic nerve, rabbit, retinal ganglion cell, retinitis pigmentosa
The authors report the histopathological changes of retinal ganglion cells (RGCs), optic disc and optic nerve in rabbit with advanced retinitis pigmentosa (RP). RP was recreated in rabbits by using bacterial artificial chromosome transgenesis, with the purpose of increasing understanding...
Retinal changes in Leber hereditary optic neuropathy
1 August 2016
| Claire Howard
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EYE - Neuro-ophthalmology
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Ganglion cell complex, Leber hereditary optic neuropathy, optical coherence tomography, retinal nerve fibre layer
The objective of this study was to describe the changes in the retinal ganglion cell complex (GCC) relative to the retinal nerve fibre layer (RNFL) over time, in patients with Leber’s hereditary optic neuropathy (LHON). For this study, 21 patients...
PD-1 and retinal ganglion cell death
1 February 2016
| Graham Wallace
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Apoptosis, Large retinal ganglion cells, Neuroprotection, Optic nerve crush, Programmed cell death-1
Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...
A case series of acute visual loss following excessive alcohol and / or drug use
1 August 2015
| Claire Howard
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EYE - Neuro-ophthalmology
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Ophthalmoplegia, retinal artery occlusion, saturday night retinopathy
This study presents three cases of so called Saturday night retinopathy, an acute visual loss following intravenous drug abuse and stupor, leading to continuous pressure on the orbit while asleep. All three cases presented with acute vision loss and had...
