Vitreoretinal lymphoma: The importance of cerebral spinal fluid evaluation at initial diagnosis
Reviewed by Jonathan Chan

This is a retrospective single centre case observational study between 2006 and 2024 at Memorial Sloan Kettering Cancer Center, to review patients with biopsy-proven central nervous system lymphoma and MRI brain evaluation. Sixth-five patients were included in this study, 11 (16.9%) had cerebrospinal fluid (CSF) suspicious for lymphoma without positive findings on MRI of the brain. In this subgroup, the median age was 66 years and 36% were female, 86% of these patients were asymptomatic neurologically, 73% had systemic treatment and 91% of these patients were living at a mean of three years follow-up. The authors concluded that all patients with either a confirmed diagnosis, or suspicious of vitreoretinal lymphoma should have a lumbar puncture to evaluate CSF for disease.

Vitreoretinal lymphoma (VRL): the importance of cerebral spinal fluid evaluation at initial diagnosis.
Silverman RF, Abramson DH, Canestraro J, et al.
BRITISH JOURNAL OF OPHTHALMOLOGY
2025;109:504–9.