You searched for "carcinoma"

66 results found

PD-1 and PD-L1 in exenteration specimens

This is an immunohistochemical study looking at variation in the expression of the programmed death-1 receptor (PD-1) and the programmed cell death ligand-1 (PD-L1), comparing cutaneous malignancies which invaded the orbit with uncomplicated nodular basal cell carcinomas. The authors retrospectively...

Carcinoid tumours

This is a retrospective review of 28 patients with carcinoid tumours affecting the orbit. The mean age at presentation of the orbital involvement was 62 years, with a slight female preponderance, and 21% had carcinoid syndrome. Proptosis and diplopia were...

Periocular sweat gland carcinomas

This is an interesting review of a rare group of tumours which together comprise the adnexal sweat gland carcinomas. Although there are only 22 patients, this is the largest cohort ever published. The authors summarise the clinical presentation, stage, management...

Keratolimbal allograft and tumour transmission

This case report describes tumour transmission from keratolimbal allograft donor to recipient. A 68-year-old woman underwent keratolimbal allograft (KLAL) for limbal stem cell failure from a donor, who died of invasive breast carcinoma that had metastasised to multiple levels of...

Combined Vismodegib and Mohs surgery

This is a report of eight patients with locally advanced periocular basal cell carcinoma who were treated with Vismodegib prior to Mohs micrographic surgery. The rationale for the combined treatment plan was that long-term Vismodegib is poorly tolerated due to...

Lacrimal drainage system malignancies

This retrospective case series looks at the rare cases of lacrimal drainage system malignancies. The authors have identified 14 patients in 24 years, at a tertiary referral centre in the Indian subcontinent. Many previous publications have found squamous cell carcinoma...

Amblyopia treatment review

This review paper summarises the main causes and neural mechanisms that characterise amblyopia. The authors analysed neuroanatomical, neurophysiological and electrophysiological studies in the literature to better understand actual treatment regimens and evaluate new therapeutic possibilities. They considered causes of strabismus,...

Oct/Nov 2017 Quiz

History A 73-year-old man presented with a rapidly growing left lower eyelid lump with recent bleeding. On examination there was a raised, ulcerated, firm mass occupying two thirds of his lower eyelid. The lesion bled easily and appeared connected to...

Aug/Sep 2014 Quiz 1

History A 50-year-old female with a history of smoking, weight loss and cough presents to the ophthalmology clinic with a distorted pupil. Examination reveals a mass on the surface and within the iris (see Figure 1). The ophthalmologists decide to...

A phase 3 randomised trial of nicotinamide for skin cancer chemoprevention

To B3, or not to B3? That was the question asked in this controlled trial in which the authors were able to show that oral nicotinamide (vitamin B3) is able to reduce further skin cancer development in high risk patients....

Staged excision of primary periocular BCC

This is a 10 retrospective review of case notes study of 437 patients of staged basal cell carcinoma (BCC) excisions between 2000 and 2017. All patients had 3mm clinically clear margins with staged excision and standard reconstruction techniques were performed...

Paraneoplastic optic neuropathy features

This is a retrospective review of seven patients diagnosed with paraneoplastic optic neuropathy (PON) between January 2015 and June 2017. Five patients had a history of primary malignancy, including papillary thyroid carcinoma, type B thymoma, testicular seminoma and lung carcinoma....